Amvuttra (vutrisiran)
Patient Assistance Program Guide — Alnylam Assist
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured, underinsured, or patients with commercial insurance/Medicare who meet financial criteria and lack coverage for the medication.
Residency
U.S. resident with valid address
Income Limits (500% FPL)
Specific income caps are not always explicitly stated by Alnylam but are generally benchmarked at 500% FPL for rare disease therapies; cases are reviewed individually based on financial need.
Based on 2025 HHS Federal Poverty Level guidelines.
# Alnylam Assist Patient Assistance Program for Amvuttra (vutrisiran): A Complete Guide
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Who Qualifies for the Alnylam Assist?
If you have been prescribed Amvuttra (vutrisiran) and cannot afford it, you may be able to get it at little or no cost through the Alnylam Assist program. This program is open to patients who are uninsured, underinsured, or who have commercial insurance or Medicare but do not have adequate coverage for Amvuttra. For a single-person household, the general income limit is $75,300 per year. You do not need to have insurance to apply, but patients with Medicaid coverage are typically not eligible. If you meet the financial and insurance criteria, Alnylam Assist may be able to provide Amvuttra at no cost to you. Each application is reviewed individually, so it is worth applying even if you are unsure whether you qualify.
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About Amvuttra (vutrisiran)
Amvuttra (vutrisiran) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat polyneuropathy caused by hereditary transthyretin-mediated (hATTR) amyloidosis in adults. It belongs to a drug class called transthyretin-directed small interfering RNA (siRNA) therapy. Amvuttra works by targeting a specific genetic process in the liver. Because it treats a rare, serious genetic condition and requires specialized manufacturing, its list price is very high — often several hundred thousand dollars per year — making it unaffordable for many patients without financial support. There are currently no FDA-approved biosimilar versions of Amvuttra available, which means the brand-name drug is the only option.
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Income Eligibility: Full Breakdown
Alnylam Assist uses household size and annual income to determine financial eligibility. The general income guidelines are as follows:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
These thresholds are generally benchmarked at approximately 500% of the Federal Poverty Level (FPL), which is common for rare disease programs. If your household is larger than four people, you may still qualify — Alnylam reviews applications individually based on financial need, so do not assume you are automatically disqualified.
Your income is typically verified using your most recent federal tax return, a W-2 form, or three months of recent pay stubs. If your income has changed significantly since last year — for example, due to job loss or reduced hours — you can often use current pay stubs to reflect your present situation rather than your prior-year income.
If your income exceeds the listed limits, Alnylam may still review your case. It is worth submitting an application or calling the program directly to discuss your circumstances before giving up on assistance.
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Insurance Requirements Explained
Your insurance situation affects how you can use Alnylam Assist. Here is how the program applies to different coverage types:
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Step-by-Step: How to Apply
Follow these steps to apply for Alnylam Assist:
1. Gather your documents. You will need: a completed Alnylam Assist Patient Enrollment Form, proof of household income (such as a federal tax return, W-2, or three months of pay stubs), your prescription information from your doctor, and your insurance card(s) if you have coverage.
2. Download or request the enrollment form. Visit the program website at https://www.alnylamassist.com/ to access the form online. You can also call (833) 256-2748 to request a form by phone.
3. Have your prescriber complete their portion. Your doctor or their office staff will need to fill out sections of the enrollment form that include your diagnosis, prescription details, and clinical information.
4. Submit your application. You have multiple ways to apply:
- Online: Submit through https://www.alnylamassist.com/
- Phone: Call (833) 256-2748 for assistance
- Fax: Send completed documents to (833) 256-2747
5. Wait for a decision. Processing typically takes 2 to 3 business days after Alnylam receives all required documents.
6. Follow up if needed. If you do not hear back within three business days, call the program to confirm your application was received and to check its status.
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What to Expect: Timeline and Delivery
Once your application is submitted with all required documents, a decision typically comes within 2 to 3 business days. Alnylam Assist will notify you and your prescriber's office of the approval. Approved medication is shipped directly to your prescriber's office, not to your home. Your doctor's office will contact you to schedule your appointment for administration. You do not need to pick up or handle the medication yourself. Alnylam Assist approval lasts for one year. Before your approval period ends, you will need to reauthorize annually by submitting updated income documentation and a new enrollment form. Your prescriber's office or the Alnylam Assist team will typically remind you when renewal is approaching.
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Alternatives If You Don't Qualify
If you do not qualify for the free patient assistance program, there are still options worth exploring:
1. Biosimilars: There are currently no FDA-approved biosimilars for Amvuttra, so this option is not yet available. This may change in the future, and it is worth monitoring.
2. Amvuttra Co-Pay Savings Card: If you have commercial (private) insurance, you may be eligible for a co-pay savings card that reduces your out-of-pocket costs. Visit https://www.alnylamassist.com/amvuttra/copay to find out more and enroll.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states run their own drug assistance programs, especially for Medicare beneficiaries. Eligibility and benefits vary by state. Contact your state's department of health or aging services to learn what is available where you live.
4. NeedyMeds.org: This free, nonprofit database at www.needymeds.org lists patient assistance programs, disease-specific funds, and other resources. It is a useful starting point if you need additional help beyond what Alnylam Assist provides.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Alnylam. Program terms may change — verify current requirements at [https://www.amvuttra.com/patient-support](https://www.amvuttra.com/patient-support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Alnylam offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Once Alnylam receives your completed application and all required documents, a decision typically takes 2 to 3 business days. Make sure your prescriber has submitted their portion of the enrollment form, as missing information is the most common cause of delays.
No. If you are approved through Alnylam Assist, your medication will be shipped directly to your prescriber's office. Your doctor's office will contact you to schedule the appropriate appointment for your treatment.
Yes. Alnylam Assist approval lasts for one year. You will need to reauthorize annually by submitting updated proof of income and a new enrollment form. Alnylam or your prescriber's office will typically notify you before your approval period expires.
Yes, Medicare patients may be eligible for Alnylam Assist if they meet the income guidelines and Amvuttra is not adequately covered by their Medicare plan. This is different from many other assistance programs that exclude Medicare patients entirely. Call (833) 256-2748 to discuss your specific situation.
Alnylam reviews applications on a case-by-case basis. If your income is close to or slightly above the listed thresholds, it may still be worth submitting an application. You can also call (833) 256-2748 to speak with a program representative before applying.
Ready to Apply for Amvuttra Assistance?
RX Advantages handles the entire Alnylam Assist application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
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