Calquence (acalabrutinib)
Patient Assistance Program Guide — AZ&Me Prescription Savings Program
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Available to uninsured patients or those with Medicare Part D who meet specific financial and prescription spend requirements.
Residency
U.S. resident or resident of a U.S. Territory
Income Limits (500% FPL)
Income threshold for AstraZeneca oncology products is typically 500% of the Federal Poverty Level.
Based on 2025 HHS Federal Poverty Level guidelines.
# Getting Calquence at Low or No Cost: Your Guide to the AZ&Me Prescription Savings Program
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Who Qualifies for the AZ&Me Prescription Savings Program?
If you have been prescribed Calquence (acalabrutinib) and are struggling with the cost, you may be able to get it free or at a significantly reduced cost through the AZ&Me Prescription Savings Program, run by AstraZeneca, the maker of Calquence. For a single-person household, your annual income must be at or below $75,300 to meet the basic financial requirement. In terms of insurance, this program is available to patients who are either uninsured or enrolled in Medicare Part D and who meet specific financial and prescription spending requirements. If you have commercial insurance, a separate savings card option may be available to you instead.
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About Calquence (acalabrutinib)
Calquence is a prescription oral medication approved by the U.S. Food and Drug Administration (FDA) to treat certain blood cancers, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL). It belongs to a drug class called Bruton's Tyrosine Kinase (BTK) inhibitors, which work by targeting specific proteins involved in cancer cell growth. Without insurance or financial assistance, Calquence can cost tens of thousands of dollars per year, placing it out of reach for many patients. No FDA-approved biosimilar versions of Calquence are currently available, which means there is no automatic lower-cost substitute at this time.
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Income Eligibility: Full Breakdown
The AZ&Me Prescription Savings Program uses income thresholds set at approximately 500% of the Federal Poverty Level. The limits by household size are:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Your income is typically verified using your most recent federal tax return, a W-2, or a 1099 form. If your tax documents are not available, three months of recent pay stubs may be accepted as an alternative.
If your income is above these limits, you may not qualify for the free medication program — but you are not necessarily out of options. The program does have some flexibility, and it is worth calling AstraZeneca directly at (800) 292-6363 to discuss your specific situation. Additionally, the savings card program and other assistance options described later in this guide may still be available to you regardless of income. Household size can make a meaningful difference in your eligibility, so be sure you are counting all members of your household when you apply.
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Insurance Requirements Explained
Your current insurance coverage plays a major role in determining which part of the program you can access. Here is how the different scenarios work:
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Step-by-Step: How to Apply
Follow these steps to apply for the AZ&Me Prescription Savings Program for Calquence:
1. Gather your documents. You will need: a completed and signed application form, proof of income (your most recent tax return, W-2, 1099, or three months of pay stubs), and a valid prescription for Calquence from your doctor.
2. Choose your application method. You have three options:
- Online: Visit https://www.azandmeapp.com/ to complete and submit your application electronically. This is often the fastest method.
- Phone: Call (800) 292-6363 to speak with a program representative who can walk you through the process.
- Fax: Fax your completed application and supporting documents to (800) 961-8323.
3. Have your prescriber involved. Your doctor or their office staff will likely need to sign part of the application and submit the valid prescription. Many practices have experience with this process — ask your oncology team for help if needed.
4. Submit your full application. Make sure all required fields are filled out and all documents are included. Incomplete applications may delay processing.
5. Wait for a decision. After submission, allow 7 to 10 business days for processing.
6. Check the program website for updates. Visit https://www.calquence.com/patient-support for the latest program information.
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What to Expect: Timeline and Delivery
Once you submit a complete application, processing typically takes 7 to 10 business days. You or your prescriber will be notified of the approval decision. If approved, your Calquence will be shipped directly to your home — you do not need to pick it up at a pharmacy or prescriber's office. There is nothing you need to do at a pickup counter. Your enrollment in the program is not permanent. Annual reauthorization is required, meaning you will need to reapply and provide updated income documentation each year to continue receiving the medication. Watch for renewal notices and plan ahead so you do not experience a gap in coverage.
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Alternatives If You Don't Qualify
If you do not qualify for the AZ&Me program, here are other paths worth exploring:
1. Biosimilars: There are currently no FDA-approved biosimilar alternatives to Calquence. This option is not available at this time.
2. Manufacturer savings card: If you have commercial (private) insurance, AstraZeneca offers a savings card that may lower your co-pay. Visit https://www.calquence.com/savings-support.html to check eligibility and enroll.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer programs that help residents — especially older adults and those with disabilities — pay for prescription drugs. Eligibility and benefits vary by state. Contact your state health department or ask your social worker for information about what is available where you live.
4. NeedyMeds.org: This free online database at https://www.needymeds.org lists hundreds of patient assistance programs, disease-based funds, and co-pay assistance options. It is a useful starting point if you are exploring multiple avenues at once.
Do not give up if one program does not work out. Multiple assistance options may be available to you depending on your situation.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by AstraZeneca. Program terms may change — verify current requirements at [https://www.calquence.com/patient-support](https://www.calquence.com/patient-support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
AstraZeneca offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Yes, Medicare Part D patients may be eligible for the AZ&Me Prescription Savings Program, but there are specific financial and prescription spending requirements that must be met. Not all Medicare Part D enrollees will qualify automatically. Call (800) 292-6363 to find out whether your situation meets the program criteria.
After submitting a complete application, processing typically takes 7 to 10 business days. Once approved, Calquence is shipped directly to your home. Make sure your application includes all required documents to avoid delays.
Yes. The AZ&Me program requires annual reauthorization. Each year, you will need to submit updated income documentation and a renewed application to continue receiving Calquence through the program. Watch for renewal reminders and plan ahead to avoid any gap in your medication supply.
If your income is above the stated threshold, you may not qualify for free medication through AZ&Me, but it is worth calling (800) 292-6363 to discuss your situation. You may also want to explore the savings card for insured patients, state pharmaceutical assistance programs, or other resources listed on NeedyMeds.org.
No. As of now, there are no FDA-approved biosimilar or generic versions of Calquence (acalabrutinib). This means the patient assistance program and savings card are currently the primary ways to reduce your out-of-pocket cost for this medication.
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