Dupixent (dupilumab)
Patient Assistance Program Guide — Sanofi Patient Connection
Do You Qualify?
Income
Up to $60,240 for a single person
Insurance
Uninsured, underinsured (insurance does not cover the drug), or Medicare patients who meet specific criteria for lack of coverage.
Residency
U.S. resident or resident of U.S. Territories
Income Limits (400% FPL)
Calculated based on 400% of 2025 Federal Poverty Level (FPL). Some cases may be reviewed for medical necessity if income exceeds these limits.
Based on 2025 HHS Federal Poverty Level guidelines.
# Getting Dupixent for Free or at Low Cost Through Sanofi Patient Connection
Who Qualifies for the Sanofi Patient Connection?
If you need Dupixent but cannot afford it, you may be able to get it at no cost through the Sanofi Patient Connection patient assistance program. This program is specifically designed to help people who are uninsured, underinsured, or on Medicare who meet certain income and coverage criteria. For a single-person household, your annual income must generally be at or below $60,240 to qualify. Your insurance status matters just as much as your income — you must either have no insurance or have insurance that does not adequately cover Dupixent. If you meet these basic criteria, this program may provide your medication at no charge, shipped directly to your home.
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About Dupixent (dupilumab)
Dupixent (dupilumab) is a biologic injection made by Sanofi and Regeneron. It belongs to a drug class called interleukin-4 receptor alpha (IL-4Rα) antagonists. The FDA has approved Dupixent to treat several conditions, including moderate-to-severe atopic dermatitis, moderate-to-severe asthma, chronic rhinosinusitis with nasal polyposis, eosinophilic esophagitis, and prurigo nodularis. Because it is a biologic — meaning it is derived from living cells and requires specialized manufacturing — Dupixent carries a high list price that can reach tens of thousands of dollars per year without insurance or assistance. There are currently no FDA-approved biosimilar versions of dupilumab available, which means lower-cost generic-style alternatives do not yet exist.
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Income Eligibility: Full Breakdown
Sanofi Patient Connection uses income thresholds based on 400% of the 2025 Federal Poverty Level (FPL). Here is how the limits break down by household size:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $60,240 |
| 2 persons | $81,760 |
| 3 persons | $103,280 |
| 4 persons | $124,800 |
If your household has more than four people, the limit increases with each additional member. When calculating household size, include everyone in your home who files taxes together or shares financial resources.
To verify your income, you will typically need to provide your most recent federal tax return, a W-2 form, or your three most recent pay stubs. If your income does not appear neatly in these documents — for example, if you are self-employed or have variable income — contact the program directly for guidance on acceptable alternatives.
If your income is above these limits, do not assume you are automatically disqualified. Sanofi may review some cases on the basis of medical necessity if your situation involves exceptional financial hardship or unusually high out-of-pocket costs. It is worth calling the program to ask before giving up on the application.
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Insurance Requirements Explained
Your insurance situation determines whether and how you can use this program:
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Step-by-Step: How to Apply
Follow these steps to apply for the Sanofi Patient Connection program:
1. Gather your documents before you start. You will need: a completed patient application, your prescriber's signed prescription and their completed application section, proof of income (most recent tax return, W-2, or three months of pay stubs), and copies of any insurance cards you currently have.
2. Choose your application method. You have three options:
- Online: Visit https://www.sanofipatientconnection.com/ to complete and submit your application digitally. This is often the fastest method.
- Phone: Call (888) 847-4877 to speak with a program representative who can walk you through the process.
- Fax: Download a paper application and fax the completed forms along with your supporting documents to (888) 847-1797.
3. Have your prescriber complete their section. The application requires both a patient section and a prescriber section. Ask your doctor's office to complete and sign their portion before submission.
4. Submit everything together. Incomplete applications are a common cause of delays. Double-check that all sections are filled out and all documents are included before sending.
5. Wait for confirmation. After submission, the program typically processes applications within 2 to 3 business days. You should receive notice of your approval status by phone or mail.
6. Confirm your shipping details. Once approved, Dupixent will be shipped directly to your home address. Make sure the address on your application is current and that someone will be available to receive temperature-sensitive medication.
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What to Expect: Timeline and Delivery
Most applications are reviewed within 2 to 3 business days of receipt. Once approved, you will be notified directly, and your medication will be shipped to your home — you do not need to pick it up at a pharmacy or your doctor's office. Because Dupixent is a biologic that requires refrigeration, make sure you can receive the package promptly upon delivery.
Your approval is not permanent. The Sanofi Patient Connection requires annual reauthorization, meaning you will need to reapply each year to confirm that you still meet the income and insurance eligibility requirements. You will typically be contacted before your current authorization period ends, but it is a good idea to track your renewal date and begin gathering updated documents — such as a new tax return — a few weeks in advance.
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Alternatives If You Don't Qualify
If you do not qualify for the Sanofi Patient Connection, you still have options:
1. Biosimilars: There are currently no FDA-approved biosimilars for dupilumab. This option is not available yet, but may become available in future years.
2. Manufacturer savings card for insured patients: If you have commercial insurance, you may qualify for the Dupixent MyWay Copay Card, which can significantly reduce your out-of-pocket cost. Learn more at https://www.dupixent.com/support-savings/copay-card. Note that this card is generally not available to Medicare or Medicaid patients.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states run their own programs to help residents afford high-cost medications. Eligibility and benefits vary by state. Contact your state health department or insurance commissioner's office to find out what is available where you live.
4. NeedyMeds.org: This free, independent database at https://www.needymeds.org lists patient assistance programs, disease-specific funds, and other resources. It is a useful starting point if you need to explore multiple options at once.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Sanofi / Regeneron. Program terms may change — verify current requirements at [https://www.dupixent.com/support-and-savings/patient-assistance-program](https://www.dupixent.com/support-and-savings/patient-assistance-program) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Sanofi / Regeneron offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Most applications are processed within 2 to 3 business days after Sanofi receives a complete application. Delays most often happen when documents are missing or the prescriber section is not fully completed. Submitting everything together online tends to be the fastest approach.
Yes, Medicare patients may qualify if their Part D plan does not adequately cover Dupixent. The program evaluates these situations on a case-by-case basis. Call (888) 847-4877 to discuss your specific Medicare coverage before applying.
The Sanofi Patient Connection requires annual reauthorization. Each year, you will need to reconfirm your income and insurance status. Sanofi typically notifies you before your approval expires, but it is a good idea to prepare updated income documents a few weeks before your renewal date to avoid any gap in your medication supply.
Yes, it may still be worth applying or calling the program. Sanofi may review cases that exceed the standard income limits if there are significant medical or financial hardship factors involved. You can reach the program at (888) 847-4877 to ask whether your situation qualifies for a medical necessity review.
For patients who qualify through the Sanofi Patient Connection, Dupixent is typically provided at no cost. The medication is shipped directly to your home. If you have commercial insurance and do not qualify for the patient assistance program, the Dupixent MyWay Copay Card may help reduce your out-of-pocket costs instead.
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