Enhertu (trastuzumab deruxtecan)

Do You Qualify?

Income Limits (500% FPL)

AstraZeneca oncology medications generally use 500% FPL as the income threshold.

Based on 2025 HHS Federal Poverty Level guidelines.

# Getting Enhertu at No Cost Through the AZ&Me Prescription Savings Program

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Who Qualifies for the AZ&Me Prescription Savings Program?

If you have been prescribed Enhertu (trastuzumab deruxtecan) and cannot afford it, you may be able to get it at no cost through the AZ&Me Prescription Savings Program, run by AstraZeneca. To qualify, your annual household income generally must be at or below $75,300 for a single-person household. Income limits are higher for larger households. You must also be uninsured or meet specific Medicare Part D eligibility requirements — patients with active commercial insurance coverage for Enhertu are not eligible for this program. If you meet these criteria, this guide walks you through exactly how to apply, what documents you need, and what to expect after you submit your application.

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About Enhertu (trastuzumab deruxtecan)

Enhertu is a prescription medicine made by AstraZeneca and Daiichi Sankyo. It belongs to a class of drugs called HER2-directed antibody-drug conjugates (ADCs). It is FDA-approved to treat several serious cancers, including HER2-positive and HER2-low breast cancer, HER2-mutant non-small cell lung cancer (NSCLC), HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma, and certain other HER2-positive solid tumors. As a specialty biologic infusion therapy, Enhertu carries a very high list price — often tens of thousands of dollars per treatment cycle — which places it out of reach for many patients without insurance or financial assistance. No FDA-approved biosimilar versions are currently available, which means this program may be the primary path to affordable access for eligible patients.

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Income Eligibility: Full Breakdown

AstraZeneca uses approximately 500% of the Federal Poverty Level (FPL) as the income threshold for its oncology programs, including the AZ&Me Prescription Savings Program for Enhertu. The income limits by household size are:

| Household Size | Maximum Annual Income |

|---|---|

| 1 person | $75,300 |

| 2 persons | $102,200 |

| 3 persons | $129,100 |

| 4 persons | $156,000 |

For households larger than four people, income limits continue to increase. Contact the program directly at (800) 292-6363 to ask about your specific household size.

Income is typically verified using your most recent federal tax return, a W-2, or a 1099 form. If your income has dropped recently — for example, due to job loss or retirement — you may be able to submit three months of recent pay stubs or other documentation instead.

If your income is above the limit, you are not automatically disqualified from all assistance. See the "Alternatives If You Don't Qualify" section below for other options that may still help reduce your costs.

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Insurance Requirements Explained

Your insurance status plays a major role in whether you qualify for the AZ&Me Prescription Savings Program. Here is how different situations are handled:

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Step-by-Step: How to Apply

Follow these steps to apply for the AZ&Me Prescription Savings Program for Enhertu:

1. Gather your documents. You will need: a completed application signed by both you and your prescriber, proof of household income (such as a federal tax return, W-2, or 1099), and a valid prescription for Enhertu.

2. Choose your application method. You have three options:

- Online: Visit https://www.azandmeapp.com/ to start and submit your application digitally.

- By phone: Call (800) 292-6363 to apply with the help of a program representative or to ask questions before you apply.

- By fax: Fax your completed application and supporting documents to (800) 961-8323.

3. Have your prescriber complete their section. The application requires your doctor's signature and prescriber information. Many offices are familiar with this process — ask your oncology care team for help if needed.

4. Submit all documents together. Incomplete applications are a common cause of delays. Double-check that all pages are signed and that your income documents are included before submitting.

5. Track your application. After submission, you can call (800) 292-6363 to check on the status of your application if you have not received a response within 10 business days.

6. Visit https://www.enhertu.com/patient-support for the most current program forms and instructions before you begin.

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What to Expect: Timeline and Delivery

After submitting a complete application, processing typically takes 7 to 10 business days. You or your prescriber's office will be notified of the approval decision. If approved, Enhertu will be shipped directly to your prescriber's office — not to your home. Your care team will coordinate when and how you receive the medication as part of your treatment schedule. You do not need to pick it up from a pharmacy.

Approval is not permanent. The AZ&Me program requires annual reauthorization, meaning you will need to reapply and re-verify your eligibility once per year. Your prescriber's office can help you stay on track with this renewal to avoid any gap in your medication supply.

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Alternatives If You Don't Qualify

If you do not qualify for the AZ&Me Prescription Savings Program, there are still options worth exploring:

1. Biosimilars: There are currently no FDA-approved biosimilars for Enhertu (trastuzumab deruxtecan). This option is not available at this time.

2. Manufacturer savings card (for insured patients): If you have commercial insurance, AstraZeneca offers a separate affordability support program through Enhertu Access 360. Visit https://www.enhertu-access360.com/enhertu/patient/affordability-support.html to see if a co-pay savings card or other support may reduce your out-of-pocket costs.

3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer their own programs to help residents — especially seniors and people with disabilities — pay for high-cost medications. Search for your state's program through your state health department website.

4. NeedyMeds.org: This free, independent database lists hundreds of patient assistance programs, co-pay assistance funds, and disease-specific resources. Visit https://www.needymeds.org and search by drug name or condition to find additional options that may apply to your situation.

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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by AstraZeneca / Daiichi Sankyo. Program terms may change — verify current requirements at [https://www.enhertu.com/patient-support](https://www.enhertu.com/patient-support) before applying.*

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