Entresto (sacubitril/valsartan)
Patient Assistance Program Guide — Novartis Patient Assistance Foundation (NPAF)
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured or underinsured; Medicare Part D patients must demonstrate financial hardship and meet specific criteria.
Residency
U.S. resident or U.S. territory resident (Puerto Rico, US Virgin Islands, Guam)
Income Limits (500% FPL)
Income threshold calculated at 500% of 2025 FPL. Program covers uninsured and underinsured patients.
Based on 2025 HHS Federal Poverty Level guidelines.
# Getting Entresto for Free or at Low Cost: A Guide to the Novartis Patient Assistance Foundation (NPAF)
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Who Qualifies for the Novartis Patient Assistance Foundation (NPAF)?
If you have been prescribed Entresto (sacubitril/valsartan) and cannot afford it, you may qualify to receive it at no cost through the Novartis Patient Assistance Foundation (NPAF). This program is designed specifically for patients who are uninsured or underinsured and meet income guidelines. For a single-person household, your annual income must be at or below $75,300 to be considered eligible. Patients with private insurance that does not adequately cover Entresto may also qualify, while Medicare Part D enrollees may be eligible under specific hardship criteria. If you meet these basic requirements, the NPAF may be able to supply your Entresto at no charge, shipped directly to your home.
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About Entresto (sacubitril/valsartan)
Entresto is a prescription medication approved by the FDA to treat adults with heart failure. It belongs to a drug class called Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) and is used for patients with both reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF), generally classified as NYHA Class II through IV heart failure. Entresto is a brand-name medication with no FDA-approved generic or biosimilar currently available, which means there is no lower-cost substitute on pharmacy shelves. Without insurance or assistance, the monthly cost of Entresto can be several hundred dollars or more, making it out of reach for many patients on fixed or limited incomes.
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Income Eligibility: Full Breakdown
The NPAF uses income thresholds set at 500% of the 2025 Federal Poverty Level (FPL). The table below shows the maximum annual household income allowed for each household size:
| Household Size | Max Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Your income is typically verified using your most recent federal tax return, a W-2, or a 1099 form. If your income has changed recently, some programs also accept three months of recent pay stubs as supporting documentation — check with the NPAF directly to confirm what they will accept in your situation.
If your income is above these limits, you may not qualify for the free medication program. However, you are not necessarily out of options. Insured patients who earn too much for NPAF may still benefit from the Entresto savings card (covered in the Alternatives section below). If your household size has recently changed — for example, due to marriage, divorce, or a dependent joining or leaving your home — make sure to report your current household composition accurately, as this directly affects your eligibility threshold.
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Insurance Requirements Explained
Your insurance status plays a major role in whether you qualify for the NPAF. Here is how different situations are typically handled:
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Step-by-Step: How to Apply
Follow these steps to apply for the Novartis Patient Assistance Foundation program for Entresto:
1. Gather your documents. You will need: proof of household income (a federal tax return, W-2, or 1099), a signed patient authorization form, and a valid prescription for Entresto from your doctor.
2. Choose your application method. The NPAF accepts applications through multiple channels:
- Online: Visit https://www.novartis.com/us-en/patients-and-caregivers/patient-assistance/novartis-patient-assistance-foundation-inc to start your application.
- By phone: Call (800) 277-2254 to speak with a program representative who can guide you through the process.
- By fax: You may fax your completed application and supporting documents to (888) 891-4924.
3. Have your prescriber involved. Your doctor will need to provide or co-sign portions of the application, including the valid prescription. Let your prescriber's office know you are applying so they can respond promptly.
4. Submit all documents together. Incomplete applications slow down processing. Make sure your income documentation and signed authorization form are included with your prescription.
5. Wait for review. The NPAF typically completes its review within two business days of receiving a complete application.
6. Watch for confirmation. You will be notified of the decision, and if approved, your medication will be arranged for shipment.
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What to Expect: Timeline and Delivery
Once the NPAF receives your complete application, the review process typically takes two business days. If approved, you will be notified of your enrollment. Entresto is shipped directly to your home address, so you will not need to visit a pharmacy or your doctor's office to pick it up. There is nothing you need to do at the time of delivery beyond receiving the package. Your approval is valid for one year, after which you will need to reauthorize your enrollment. You will typically need to resubmit updated income documentation and a new prescription at that time. Mark your calendar so you do not experience a gap in coverage.
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Alternatives If You Don't Qualify
If you do not meet the NPAF income or insurance requirements, here are other options to explore:
1. Biosimilars: There are currently no FDA-approved biosimilars or generics for Entresto. This option is not available at this time.
2. Entresto Savings Card (for insured patients): If you have commercial insurance, you may be eligible for a savings card that reduces your out-of-pocket cost at the pharmacy. You can access this program at https://www.entresto.com/financial-resources/savings-card.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states run their own drug assistance programs, particularly for older adults and people with disabilities. Check with your State Health Insurance Assistance Program (SHIP) or your state's department of aging to learn what is available where you live.
4. NeedyMeds.org: This free, independent database at www.needymeds.org allows you to search for patient assistance programs, coupons, and disease-based assistance funds that may help cover Entresto or related costs.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Novartis. Program terms may change — verify current requirements at [https://www.entresto.com/getting-entresto/heart-failure-financial-support](https://www.entresto.com/getting-entresto/heart-failure-financial-support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Novartis offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
The NPAF typically completes its review within two business days of receiving a complete application. Make sure all required documents — your income proof, signed authorization form, and valid prescription — are included to avoid delays.
Yes, but Medicare Part D patients are not automatically eligible. You must demonstrate financial hardship and meet specific criteria set by the NPAF. Call (800) 277-2254 to discuss your situation with a program representative before submitting an application.
If you are approved through the NPAF, your Entresto will be shipped directly to your home. You do not need to visit a pharmacy or your doctor's office to receive it.
You will need to reauthorize your enrollment each year. This typically means submitting updated income documentation and a new valid prescription. Plan ahead to reapply before your current approval expires so you do not run out of medication.
No. As of now, there are no FDA-approved generics or biosimilars for Entresto (sacubitril/valsartan). If you do not qualify for the NPAF program, consider the Entresto savings card for insured patients or explore options at NeedyMeds.org.
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