Eylea (aflibercept)
Patient Assistance Program Guide — Regeneron Patient Assistance Program
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Patient must be uninsured, or have insurance that does not cover the drug, or be a Medicare patient who cannot afford their cost-share.
Residency
U.S. resident or resident of Puerto Rico with valid address
Income Limits (500% FPL)
Calculated based on 500% of the 2025 FPL. Financial hardship is also considered.
Based on 2025 HHS Federal Poverty Level guidelines.
# Getting Eylea (Aflibercept) at No Cost Through the Regeneron Patient Assistance Program
Who Qualifies for the Regeneron Patient Assistance Program?
If you cannot afford Eylea (aflibercept), the Regeneron Patient Assistance Program may be able to provide it to you at no cost. This program is designed for patients who are uninsured, underinsured, or on Medicare and struggling to cover their out-of-pocket costs. To give you a quick benchmark: if you live alone, your household income generally needs to be $75,300 or less per year to qualify. Your insurance status also matters — you must either have no insurance, have insurance that does not cover Eylea, or be a Medicare patient who cannot afford your cost-share. If you meet these basic criteria, you may be a strong candidate for this program.
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About Eylea (Aflibercept)
Eylea (aflibercept) is an FDA-approved injection used to treat several serious eye conditions, including Wet Age-Related Macular Degeneration (AMD), Diabetic Retinopathy (DR), Diabetic Macular Edema (DME), Macular Edema following Retinal Vein Occlusion (RVO), and Retinopathy of Prematurity (ROP). It belongs to a class of drugs called VEGF inhibitors and works by blocking a protein that can cause abnormal blood vessel growth in the eye. Eylea is a biologic medication, meaning it is complex to manufacture, which contributes to its high cost. Without insurance or financial assistance, a single injection can cost several thousand dollars, making ongoing treatment financially out of reach for many patients.
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Income Eligibility: Full Breakdown
The Regeneron Patient Assistance Program uses income thresholds based on 500% of the 2025 Federal Poverty Level (FPL). Here is the full breakdown by household size:
| Household Size | Max Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
If your household has more than four people, the income limit increases with each additional member. If your income is slightly above the limit, you are not automatically disqualified — Regeneron also considers financial hardship on a case-by-case basis. It is worth applying even if you are close to the cutoff.
Your income is typically verified using your most recent federal tax return, W-2 forms, or three months of recent pay stubs. If you receive Social Security benefits, a Social Security Award Letter is also accepted. Make sure the documents you submit reflect your current household income as accurately as possible, since the review is based on your actual financial situation.
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Insurance Requirements Explained
Your insurance status plays a key role in whether you qualify. Here is how different situations are handled:
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Step-by-Step: How to Apply
Follow these steps to apply for the Regeneron Patient Assistance Program:
1. Gather your documents before you start. You will need: a valid Eylea prescription from your doctor, proof of household income (tax return, W-2, pay stubs, or Social Security Award Letter), and your insurance information if applicable.
2. Choose your application method. You can apply online, by phone, or by fax.
- Online: Visit https://www.regeneronhealthcaresolutions.com/eylea to complete a digital application.
- Phone: Call (855) 395-3248 to apply with a program representative or ask questions about your eligibility.
- Fax: Submit a completed application by fax to (844) 939-5324.
3. Complete the application with your prescriber. Both you and your doctor must sign the application. Your prescriber's office can often help coordinate this, and many are familiar with the process.
4. Submit your income documents along with the signed application. Make sure all documents are legible and current.
5. Wait for a determination. Processing typically takes 2–3 business days after Regeneron receives your complete application.
6. Your prescriber's office will be notified of the decision. If approved, medication is shipped directly to your prescriber's office, not your home.
7. Schedule your injection appointment as you normally would. Your doctor's office will have the medication ready when you arrive.
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What to Expect: Timeline and Delivery
Once you submit a complete application, Regeneron typically processes it within 2–3 business days. You or your prescriber's office will receive confirmation of approval. Eylea is shipped directly to your prescriber, so you do not need to pick it up at a pharmacy or make any separate arrangements. Simply attend your scheduled injection appointment as usual.
To keep receiving Eylea at no cost, you will need to reauthorize your enrollment once a year. Regeneron will generally prompt your prescriber when it is time to renew. Be prepared to submit updated income documentation at that time to confirm you still meet the eligibility requirements.
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Alternatives If You Don't Qualify
If you do not qualify for the Regeneron Patient Assistance Program, there are still options worth exploring:
1. Biosimilar alternatives: Two FDA-approved biosimilars to Eylea are available — Opuviz (aflibercept-yszy) and Yesafili (aflibercept-jbvf). These may cost less and have their own assistance programs. Ask your doctor whether a biosimilar is appropriate for your condition.
2. Savings card for insured patients: If you have commercial insurance, Regeneron offers a copay card that may reduce your out-of-pocket costs. You can access it at https://www.eylea.us/copay-card.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer their own drug assistance programs, especially for seniors and people with disabilities. Contact your state's department of health or aging to find out what is available in your area.
4. NeedyMeds.org: This free online database lists hundreds of patient assistance programs by drug name, condition, or manufacturer. Visit NeedyMeds.org to search for additional resources.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Regeneron. Program terms may change — verify current requirements at [https://www.eylea.us/patient-resources/insurance-and-financial-assistance](https://www.eylea.us/patient-resources/insurance-and-financial-assistance) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Biosimilar / Generic Alternatives
FDA-approved alternatives to Eylea: Opuviz (aflibercept-yszy), Yesafili (aflibercept-jbvf). Ask your prescriber if one of these is clinically appropriate for your condition.
Manufacturer Savings Card (for insured patients)
Regeneron offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Once Regeneron receives your complete application — including signed forms from both you and your doctor, income documents, and a valid prescription — processing typically takes 2 to 3 business days. Delays can happen if documents are missing or incomplete, so make sure everything is included before submitting.
Yes, Medicare patients may still qualify. Unlike many manufacturer programs, the Regeneron Patient Assistance Program does make exceptions for Medicare beneficiaries who cannot afford their cost-share. Call (855) 395-3248 to discuss your specific Medicare plan and coverage situation.
No. If your application is approved, Eylea is shipped directly to your prescriber's office, not to your home address. You will receive your injection at your doctor's office just as you normally would. Your prescriber will let you know when the medication has arrived.
You will need to reauthorize your enrollment every year to continue receiving Eylea through the program. This means submitting updated income documentation and a new signed application. Your prescriber's office is usually notified when renewal is due, so staying in contact with them can help you avoid a gap in treatment.
Yes, it is worth applying. The program considers financial hardship in addition to the standard income thresholds. Factors like high medical expenses, a recent job loss, or other financial pressures may be taken into account. A program representative at (855) 395-3248 can help you understand your options before you apply.
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