Fasenra (benralizumab)
Patient Assistance Program Guide — AZ&Me Prescription Savings Program
Do You Qualify?
Income
Up to $60,240 for a single person
Insurance
Must be uninsured or have Medicare Part D coverage and meet specific financial and clinical criteria. Commercially insured patients are generally ineligible for PAP but may qualify for the savings card.
Residency
U.S. resident with valid address
Income Limits (400% FPL)
Calculated based on 400% of the 2025 FPL. Higher thresholds may apply for Medicare patients with high out-of-pocket drug costs.
Based on 2025 HHS Federal Poverty Level guidelines.
# AZ&Me Prescription Savings Program: A Patient Guide for Fasenra (Benralizumab)
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Who Qualifies for the AZ&Me Prescription Savings Program?
If you have been prescribed Fasenra (benralizumab) for severe eosinophilic asthma and are struggling with the cost, the AZ&Me Prescription Savings Program — run by AstraZeneca — may be able to provide your medication at little or no cost. For a single-person household, your annual income must be at or below $60,240 to meet the basic financial threshold. In terms of insurance, you must either be uninsured or have Medicare Part D coverage to be eligible for the patient assistance program (PAP); most patients with active commercial insurance are not eligible for the PAP but may have access to a separate savings card program. If you meet these core criteria, applying is straightforward and free.
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About Fasenra (Benralizumab)
Fasenra (benralizumab) is a prescription biologic medication manufactured by AstraZeneca. It is approved by the U.S. Food and Drug Administration (FDA) as an add-on maintenance treatment for adults with severe eosinophilic asthma. Fasenra belongs to a drug class known as interleukin-5 receptor alpha directed cytolytic monoclonal antibodies, meaning it targets a specific protein involved in eosinophil activity. As a biologic medication, Fasenra is significantly more expensive than traditional drugs — list prices can reach tens of thousands of dollars per year — making it out of reach for many patients without insurance coverage or financial assistance. There are currently no FDA-approved biosimilar alternatives available for Fasenra.
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Income Eligibility: Full Breakdown
The AZ&Me program uses income thresholds based on 400% of the 2025 Federal Poverty Level (FPL). The limits by household size are:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $60,240 |
| 2 persons | $81,760 |
| 3 persons | $103,280 |
| 4 persons | $124,800 |
Your household size includes everyone in your home who you financially support, so it is worth counting carefully before assuming you are ineligible.
Income is typically verified using your most recent federal tax return, W-2 forms, 1099 forms, or three months of recent pay stubs. If your income has recently changed — for example, due to job loss or retirement — you may be able to document your current situation using pay stubs rather than last year's tax return.
If your income is above these limits, you may still want to apply, as Medicare patients with high out-of-pocket drug costs may qualify under higher thresholds. If you do not qualify for the PAP, review the alternatives section below for other options that may help reduce your costs.
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Insurance Requirements Explained
Your insurance situation plays a major role in determining which type of assistance you can receive:
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Step-by-Step: How to Apply
Follow these steps to apply for the AZ&Me Prescription Savings Program for Fasenra:
1. Gather your documents. You will need: a completed and signed application form, proof of income (most recent tax return, W-2, 1099, or three months of pay stubs), a valid prescription for Fasenra from your doctor, and any insurance cards if you are currently insured.
2. Choose your application method. You have several options:
- Online: Visit https://www.azandmeapp.com/ to complete and submit your application digitally.
- By phone: Call (800) 292-6363 to apply with the help of a program representative.
- By fax: Fax your completed application and supporting documents to (800) 961-8323.
3. Have your prescriber involved. Your doctor or their office will typically need to sign a portion of the application and may be the one submitting it on your behalf, particularly if applying by fax.
4. Submit all required documents together. Incomplete applications may cause delays, so double-check that your proof of income, prescription, and signed forms are all included.
5. Wait for confirmation. After submission, processing typically takes 7 to 10 business days. You or your prescriber's office will be notified of the decision.
6. Coordinate pickup with your prescriber. If approved, your medication will be shipped directly to your prescribing doctor's office. Contact the program page at https://www.fasenra.com/savings-and-support if you have questions during the process.
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What to Expect: Timeline and Delivery
After your application is submitted, expect a processing time of 7 to 10 business days. AstraZeneca or a program representative will notify you — or your prescriber's office — of the approval decision. If approved, Fasenra will be shipped directly to your prescribing doctor's office, not to your home. You will need to coordinate with your doctor's office to schedule your injection appointment once the medication has arrived. The AZ&Me program requires annual reauthorization, meaning you will need to reapply and resubmit income documentation each year to continue receiving assistance. Your prescriber's office may help facilitate this renewal process.
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Alternatives If You Don't Qualify
If you do not qualify for the AZ&Me PAP, consider these options:
1. Biosimilars: There are currently no FDA-approved biosimilars for Fasenra (benralizumab), so a lower-cost substitution is not available at this time.
2. Fasenra Savings Card (insured patients): If you have commercial insurance, you may be eligible for the Fasenra 360 Savings Card, which can reduce your copay or out-of-pocket costs. Learn more at https://www.fasenra.com/cost-and-support/fasenra-360.html.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer their own drug assistance programs, particularly for Medicare beneficiaries. Contact your State Health Insurance Assistance Program (SHIP) or your state's department of aging to find out what may be available where you live.
4. NeedyMeds.org: This free, independent database at https://www.needymeds.org lists patient assistance programs, disease-specific funds, and other resources that may apply to your situation. It is a helpful starting point if you need to explore multiple options.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by AstraZeneca. Program terms may change — verify current requirements at [https://www.fasenra.com/savings-and-support](https://www.fasenra.com/savings-and-support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
AstraZeneca offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Both you and your doctor can be involved in the application process. While you may be able to start an application online at https://www.azandmeapp.com/, your prescribing doctor typically needs to sign the application and provide a valid prescription. Many patients find it easier to have their doctor's office handle the submission, especially when applying by fax.
The AZ&Me Prescription Savings Program requires annual reauthorization. This means you will need to resubmit your application and updated proof of income each year to continue receiving Fasenra at no or reduced cost. Your doctor's office may be able to help remind you when your renewal is due.
Yes, it is worth applying even if your income is close to or slightly above the stated threshold. Medicare patients with high out-of-pocket prescription drug costs may qualify under a higher income limit. AstraZeneca reviews applications individually, and your specific situation may be considered.
No. Medicare Part D coverage does not automatically disqualify you from the AZ&Me program. Unlike some manufacturer assistance programs that exclude all insured patients, AZ&Me may accept Medicare Part D patients who meet financial and clinical eligibility criteria. Contact the program directly at (800) 292-6363 to discuss your specific situation.
If your application is approved, Fasenra will be shipped directly to your prescribing doctor's office — not to your home address. Once your doctor's office confirms the medication has arrived, you will need to schedule an appointment for your injection. Contact your doctor's office after your approval notification to coordinate timing.
Ready to Apply for Fasenra Assistance?
RX Advantages handles the entire AZ&Me Prescription Savings Program application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month