Givlaari (givosiran)
Patient Assistance Program Guide — Alnylam Assist
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Available to uninsured patients or underinsured patients who lack coverage for the drug or have high out-of-pocket costs and meet financial criteria.
Residency
U.S. resident or U.S. territories
Income Limits (500% FPL)
Calculated based on 500% of the 2025 FPL, which is the standard benchmark for high-cost orphan drugs in the Alnylam Assist program.
Based on 2025 HHS Federal Poverty Level guidelines.
# Alnylam Assist Patient Assistance Program for Givlaari (givosiran): A Complete Guide
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Who Qualifies for the Alnylam Assist?
If you have been prescribed Givlaari (givosiran) and are struggling to afford it, you may qualify for free or significantly reduced-cost medication through the Alnylam Assist patient assistance program. This program is run directly by Alnylam, the manufacturer of Givlaari. To give you a quick benchmark: if you are a single-person household earning up to $75,300 per year, you may meet the income requirement. On the insurance side, Alnylam Assist is open to patients who are uninsured, underinsured, or who face high out-of-pocket costs that make Givlaari unaffordable — even with existing coverage. Eligibility is reviewed on a case-by-case basis, and meeting the income threshold does not automatically guarantee approval.
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About Givlaari (givosiran)
Givlaari (givosiran) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with acute hepatic porphyria (AHP), a rare and serious genetic condition that affects the liver's ability to process certain compounds, leading to recurring attacks and chronic symptoms. It belongs to a class of drugs called small interfering RNA (siRNA) therapies, which work by targeting a specific gene involved in the disease process. Because Givlaari is a specialty biologic medication used for a rare condition, it carries an extremely high list price — often exceeding $500,000 per year — making patient assistance programs like Alnylam Assist essential for many patients. There are currently no FDA-approved biosimilar versions of Givlaari.
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Income Eligibility: Full Breakdown
Alnylam Assist uses income thresholds set at 500% of the 2025 Federal Poverty Level (FPL), a standard commonly applied to high-cost orphan drugs. The table below shows the maximum annual income allowed based on your household size:
| Household Size | Max Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
For households larger than four people, income limits increase with each additional member. Contact Alnylam Assist directly at (833) 256-2747 to ask about your specific household size.
Your income is typically verified using your most recent federal tax return, a W-2 form, or three months of recent pay stubs. If your income situation has changed significantly since your last tax filing — for example, due to a job loss — you may be able to use current pay stubs or other documentation to reflect your actual financial situation.
If your income exceeds the limits above, you may not qualify for the free medication program. However, you may still have options, including manufacturer savings cards or other assistance resources covered in the final section of this guide.
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Insurance Requirements Explained
Your insurance situation plays a major role in determining how Alnylam Assist can help you. Here is a straightforward breakdown:
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Step-by-Step: How to Apply
Follow these steps to apply for Alnylam Assist for Givlaari:
1. Gather your documents. You will need: a completed and signed Alnylam Assist Enrollment Form, proof of income (such as your most recent tax return, W-2, or three months of pay stubs), and a current prescription order from your healthcare provider.
2. Get your provider involved. Your prescribing doctor or their office staff will need to sign the enrollment form. Many practices have staff who help with this process regularly.
3. Choose how to apply. You have multiple options:
- Apply online at https://www.alnylamassist.com/
- Call Alnylam Assist at (833) 256-2747 to apply by phone or get help completing your application
- Fax your completed enrollment form and documents to (833) 425-6329
4. Submit all documents together. Incomplete applications take longer to process. Double-check that all forms are signed and all income documents are included before submitting.
5. Wait for a decision. Processing typically takes 7 to 10 business days after your complete application is received.
6. Follow up if needed. If you have not heard back after 10 business days, call (833) 256-2747 to check your application status.
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What to Expect: Timeline and Delivery
Once your complete application is submitted, most patients receive a decision within 7 to 10 business days. Alnylam Assist will notify you and your healthcare provider of the outcome. If approved, your Givlaari will be shipped directly to your prescribing provider's office — not to your home. Your provider's office will coordinate with you to arrange pickup or administration of the medication, depending on how it is prescribed.
Approval through Alnylam Assist is not permanent. You will need to reapply once per year to maintain your benefits. Alnylam Assist or your provider's office may remind you when reauthorization is due. Plan ahead so your medication is not interrupted.
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Alternatives If You Don't Qualify
If you do not qualify for Alnylam Assist, there are other options worth exploring:
1. Biosimilars: There are currently no FDA-approved biosimilar versions of Givlaari, so this is not an available alternative at this time.
2. Manufacturer savings card (insured patients): If you have commercial insurance, you may be eligible for the Givlaari co-pay assistance program through Alnylam Assist. This can help reduce your out-of-pocket costs significantly. Learn more and enroll at https://www.alnylamassist.com/givlaari/commercial-copay.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer their own prescription assistance programs for residents who do not qualify for federal programs or manufacturer assistance. Search your state's health department website or ask your provider's office for local resources.
4. NeedyMeds.org: This free, nonprofit database at https://www.needymeds.org lists hundreds of patient assistance programs, disease-specific funds, and other cost-reduction resources that may apply to your situation.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Alnylam. Program terms may change — verify current requirements at [https://www.alnylam.com/patient-support-programs](https://www.alnylam.com/patient-support-programs) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Alnylam offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Once Alnylam Assist receives your complete application — including all signed forms, income documents, and a prescription from your provider — processing typically takes 7 to 10 business days. Incomplete applications may take longer, so make sure everything is included before you submit.
No. If your application is approved, Givlaari will be shipped directly to your prescribing provider's office. Your provider's team will contact you to arrange how and when you will receive or take the medication.
You may still want to contact Alnylam Assist at (833) 256-2747 to discuss your situation. In some cases, program staff can review extenuating financial circumstances. If you do not qualify for the free medication program, the commercial co-pay card at https://www.alnylamassist.com/givlaari/commercial-copay may be an option if you have private insurance.
Yes. Alnylam Assist requires annual reauthorization to continue receiving Givlaari through the program. Your eligibility and financial information will be reviewed again each year. It is a good idea to start the renewal process before your current approval period ends to avoid any gap in your medication supply.
Federal rules generally prevent manufacturer patient assistance programs from serving patients who have Medicare Part D. However, you should still contact Alnylam Assist directly at (833) 256-2747, as there may be alternative support options or resources available to help you manage your costs.
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