Krystexxa (pegloticase)
Patient Assistance Program Guide — Amgen SupportPlus for KRYSTEXXA
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Available to uninsured or underinsured patients. Medicare patients may qualify if they meet financial criteria and lack alternative coverage.
Residency
U.S. resident or U.S. territory resident with a valid address
Income Limits (500% FPL)
Calculated at 500% of the 2025 FPL; income threshold may be subject to medical expense adjustments.
Based on 2025 HHS Federal Poverty Level guidelines.
# Amgen SupportPlus for KRYSTEXXA: A Patient Guide to Getting Krystexxa at Low or No Cost
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Who Qualifies for the Amgen SupportPlus for KRYSTEXXA?
If you need Krystexxa (pegloticase) but cannot afford it, the Amgen SupportPlus for KRYSTEXXA program may be able to provide it at little or no cost. This program is open to patients who meet income and insurance requirements. For a single-person household, the maximum annual income allowed is $75,300. In general, you must be uninsured or underinsured to qualify — meaning your current insurance either does not cover Krystexxa or leaves you with costs you cannot manage. Medicare patients may also qualify depending on their financial situation and whether they have other coverage options available to them.
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About Krystexxa (pegloticase)
Krystexxa is a biologic medication manufactured by Amgen (formerly Horizon Therapeutics). It is FDA-approved to treat chronic gout in adults whose condition has not responded adequately to standard treatments. Krystexxa belongs to a drug class called urate-oxidase enzymes and is administered as an intravenous (IV) infusion in a clinical setting. Because it is a biologic drug requiring specialized manufacturing and clinical administration, the list price is significantly higher than most oral gout medications. Without insurance or financial assistance, the cost of Krystexxa can be difficult or impossible for many patients to afford.
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Income Eligibility: Full Breakdown
The Amgen SupportPlus for KRYSTEXXA program uses income thresholds set at 500% of the 2025 Federal Poverty Level (FPL). The table below shows the maximum annual household income allowed by household size:
| Household Size | Max Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
For households larger than four people, income limits increase with each additional member. Income is typically verified using your most recent federal tax return, W-2 forms, or three months of recent pay stubs. If your income is slightly above the listed limits, you may still qualify — the program may account for significant out-of-pocket medical expenses when calculating your adjusted income. It is worth applying even if you are close to the threshold. If you do not qualify based on income alone, ask the program representative whether a medical expense adjustment applies to your situation.
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Insurance Requirements Explained
Your current insurance coverage plays a major role in whether you qualify. Here is how different coverage situations are handled:
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Step-by-Step: How to Apply
Follow these steps to apply for the Amgen SupportPlus for KRYSTEXXA program:
1. Gather your documents before starting. You will need: a completed and signed application form, proof of household income (federal tax return, W-2, or three months of pay stubs), and a valid prescription for Krystexxa from your doctor.
2. Choose your application method. You can apply online at https://www.amgensupportplus.com/krystexxa, by phone at (888) 310-4417, or by fax at (833) 936-2244. All three methods are available.
3. Complete the application form. The form requires your personal information, household size, income details, and insurance information. Your prescribing doctor must also sign a portion of the form.
4. Submit your income documentation. Attach your tax return, W-2, or pay stubs along with the signed application. If faxing, include a cover sheet with your name and the program name.
5. Confirm receipt. After submitting, call (888) 310-4417 to confirm the program received your application and documents.
6. Wait for a decision. Processing typically takes 7 to 10 business days after the program receives your complete application.
7. Have your doctor's office ready to receive delivery. If approved, medication is shipped directly to your prescribing physician's office, not to your home.
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What to Expect: Timeline and Delivery
Once you submit a complete application, expect a decision within 7 to 10 business days. You or your doctor's office will be notified of the approval. Krystexxa is shipped directly to your prescribing physician or infusion center — you do not receive it at home. Because Krystexxa is given as an IV infusion, your doctor's office will schedule your infusion appointments and manage the medication on your behalf. You do not need to pick anything up yourself. Approval through this program is not permanent — you must reapply annually to continue receiving benefits. Your doctor's office or RX Advantages can help you track when reauthorization is due.
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Alternatives If You Don't Qualify
If you do not qualify for the Amgen SupportPlus for KRYSTEXXA program, here are other options to explore:
1. Biosimilars: There are currently no FDA-approved biosimilar versions of Krystexxa (pegloticase) available in the United States, so this option is not available at this time.
2. Manufacturer savings card: If you have commercial (private) insurance, you may qualify for a savings card that reduces your out-of-pocket costs. Visit https://www.krystexxa.com/patient-support/savings-and-support/ to learn more.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer programs that help residents pay for high-cost medications, particularly for seniors or people with disabilities. Search your state's health department website or ask your doctor's office for a referral.
4. NeedyMeds.org: This free, nonprofit database lists hundreds of assistance programs by drug name and condition. Visit www.needymeds.org to search for additional support options that may apply to you.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Amgen (Horizon). Program terms may change — verify current requirements at [https://www.krystexxa.com/support](https://www.krystexxa.com/support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Amgen (Horizon) offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Processing typically takes 7 to 10 business days after the program receives your complete application, including all required documents. Incomplete applications may take longer, so make sure to include your signed application form, income proof, and a valid prescription before submitting.
No. If you are approved, Krystexxa is shipped directly to your prescribing physician's office or infusion center. Because Krystexxa is given as an IV infusion in a clinical setting, you will receive the medication during your scheduled infusion appointments — not at home.
Yes, Medicare patients may qualify for the Amgen SupportPlus for KRYSTEXXA program. Eligibility depends on whether you meet the income requirements and whether you lack other adequate coverage options. Call the program at (888) 310-4417 to discuss your specific situation before assuming you do not qualify.
Approval through this program is valid for one year. After that, you must reapply and submit updated income documentation to continue receiving assistance. It is a good idea to start the reauthorization process several weeks before your current approval expires to avoid any gap in coverage.
Yes, it is still worth applying. The program may consider significant out-of-pocket medical expenses when calculating your income, which could lower your adjusted income below the threshold. A program representative can review your situation and let you know whether a medical expense adjustment applies.
Ready to Apply for Krystexxa Assistance?
RX Advantages handles the entire Amgen SupportPlus for KRYSTEXXA application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month