Kyprolis (carfilzomib)
Patient Assistance Program Guide — Amgen Safety Net Foundation
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured or underinsured; patients with commercial insurance may qualify if they have no coverage for the drug. Patients with Medicare Part D must meet specific hardship criteria.
Residency
U.S. resident or resident of U.S. territories with a valid address
Income Limits (500% FPL)
Calculated based on 500% FPL which is the standard threshold for Amgen oncology products; exact requirements should be verified during enrollment.
Based on 2025 HHS Federal Poverty Level guidelines.
# Getting Kyprolis (Carfilzomib) at No Cost Through the Amgen Safety Net Foundation
Who Qualifies for the Amgen Safety Net Foundation?
If you have been prescribed Kyprolis (carfilzomib) for multiple myeloma and cannot afford it, the Amgen Safety Net Foundation may be able to provide it to you at no cost. This program is designed specifically for patients who are uninsured, underinsured, or whose insurance does not cover Kyprolis. To give you a quick sense of the income guidelines: a single-person household may qualify with an annual income up to $75,300. Your insurance status matters too — patients with Medicare Part D may qualify only if they meet specific hardship criteria, while those with no insurance or inadequate coverage are generally eligible to apply.
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About Kyprolis (Carfilzomib)
Kyprolis (carfilzomib) is an injectable prescription medication made by Amgen. It is FDA-approved to treat adults with relapsed or refractory multiple myeloma, a type of blood cancer that has returned or stopped responding to prior treatment. Kyprolis belongs to a class of drugs called proteasome inhibitors, which work by interfering with the way cancer cells break down proteins. Because it is a specialty biologic administered in a clinical setting, Kyprolis carries a very high list price — often tens of thousands of dollars per treatment cycle — placing it out of reach for many patients without financial assistance.
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Income Eligibility: Full Breakdown
The Amgen Safety Net Foundation uses income thresholds based on 500% of the Federal Poverty Level (FPL), which is the standard Amgen uses for its oncology assistance programs. The limits by household size are:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Income is typically verified using your most recent federal tax return or three months of recent pay stubs. If your income has changed significantly since your last tax return — for example, due to job loss or a medical leave — you may be able to use current pay stubs instead.
If your income is above these limits, you may still have options. Some applicants just over the threshold are reviewed on a case-by-case basis. You can also ask the program directly whether any hardship exceptions apply to your situation. See the "Alternatives If You Don't Qualify" section below for additional resources.
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Insurance Requirements Explained
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Step-by-Step: How to Apply
Step 1: Gather your documents.
Before starting, collect the following: a completed application form signed by both you and your prescriber, proof of income (your most recent federal tax return, W-2, or three months of pay stubs), and a valid prescription for Kyprolis.
Step 2: Download or request the application.
Visit https://www.amgensafetynetfoundation.com to access the online application or to download a paper form. You can also call (866) 264-2778 to have a form mailed or faxed to you.
Step 3: Have your doctor complete their portion.
Your prescriber must sign the application. Many offices handle this routinely — ask your oncology clinic's financial navigator or medical assistant to assist with this step.
Step 4: Submit your application.
You may submit your completed application in one of three ways:
Step 5: Wait for your decision.
The program typically completes its review within 2 business days of receiving a complete application.
Step 6: Confirm next steps with your care team.
Once approved, your prescriber's office will be notified. You do not need to take additional action for pickup — medication is shipped directly to your prescriber or treatment facility.
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What to Expect: Timeline and Delivery
After submitting a complete application, you can typically expect a decision within 2 business days. Approval notification is sent to your prescriber. Kyprolis will be shipped directly to your prescriber's office or infusion center — you do not need to pick it up at a pharmacy or take any additional steps at the point of care.
Your enrollment is valid for one year. Before your approval period ends, you will need to submit a reauthorization to continue receiving the medication. Your care team or a program representative will typically notify you when renewal is due. Keep your income documents updated so the process goes smoothly.
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Alternatives If You Don't Qualify
Biosimilars: There are currently no FDA-approved biosimilar alternatives to Kyprolis. This means the Amgen Safety Net Foundation program is the primary manufacturer-based option for cost relief.
Savings card for insured patients: If you have commercial (private) insurance and do not qualify for the free drug program, Amgen offers a copay support card through Amgen SupportPlus. This card may reduce your out-of-pocket costs. Visit https://www.amgensupportplus.com/copay to learn more.
State Pharmaceutical Assistance Programs (SPAPs): Many states offer programs that help residents cover the cost of prescription drugs. Eligibility and benefits vary by state. Ask your oncology social worker or contact your state health department for details.
NeedyMeds.org: This free, nonprofit database lists hundreds of assistance programs, including disease-specific funds and state programs. Visit https://www.needymeds.org to search by drug name or condition at no cost.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Amgen. Program terms may change — verify current requirements at [https://www.kyprolis.com/support](https://www.kyprolis.com/support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Amgen offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
The program typically completes its review within 2 business days of receiving a complete application. Make sure both you and your prescriber have signed the application and that all income documents are included to avoid delays.
Yes. The Amgen Safety Net Foundation requires annual reauthorization. Your approval is valid for one year, after which you will need to submit updated documentation to continue receiving Kyprolis at no cost.
Possibly. Medicare Part D patients are not automatically disqualified, but you must meet specific financial hardship criteria to be considered eligible. Call the program at (866) 264-2778 to discuss your situation before submitting an application.
Kyprolis is shipped directly to your prescriber's office or infusion center. You do not need to pick it up at a pharmacy. Your care team will let you know when the medication has arrived.
Some applications above the standard income threshold may be reviewed individually, particularly in cases of significant medical expenses or sudden income changes. Contact the program at (866) 264-2778 to ask whether any exceptions or hardship reviews apply to your situation.
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