Leqvio (inclisiran)
Patient Assistance Program Guide — Novartis Patient Assistance Foundation (NPAF)
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Must be uninsured, underinsured, or have Medicare Part D and demonstrate financial hardship.
Residency
U.S. resident with valid address
Income Limits (500% FPL)
Calculated at 500% FPL based on standard NPAF specialty medication criteria.
Based on 2025 HHS Federal Poverty Level guidelines.
# A Patient's Guide to Getting Leqvio (inclisiran) Through the Novartis Patient Assistance Foundation (NPAF)
---
Who Qualifies for the Novartis Patient Assistance Foundation (NPAF)?
If you need Leqvio (inclisiran) but cannot afford it, you may be able to get it at little or no cost through the Novartis Patient Assistance Foundation (NPAF). This program is designed specifically for patients who lack the insurance coverage or financial resources to pay for their medication. If you are a single-person household earning up to $75,300 per year, you may meet the income requirement. On the insurance side, you must be either uninsured, underinsured, or enrolled in Medicare Part D — and you must be able to show financial hardship. If you meet these basic criteria, the NPAF may be able to provide Leqvio to you free of charge or at a significantly reduced cost.
---
About Leqvio (inclisiran)
Leqvio (inclisiran) is a prescription medication made by Novartis. It is used to treat primary hyperlipidemia, heterozygous familial hypercholesterolemia (HeFH), and atherosclerotic cardiovascular disease (ASCVD) — conditions involving high levels of LDL cholesterol in the blood. Leqvio belongs to a drug class called PCSK9-directed small interfering RNA (siRNA), which works through a different mechanism than traditional cholesterol medications. Because it is a specialty injectable medication with a novel mechanism of action, Leqvio carries a high list price that can make it difficult or impossible to afford without insurance or assistance. That is exactly what the NPAF program is intended to address.
---
Income Eligibility: Full Breakdown
The NPAF uses household size and annual income to determine whether you qualify. The income limits below are calculated at 500% of the Federal Poverty Level (FPL), which is the standard NPAF uses for specialty medications like Leqvio:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Your income is typically verified using your most recent federal tax return, a W-2 form, or three months of recent pay stubs. The program looks at your total household income, not just your own earnings, so be prepared to account for all working members of your household.
If your income is above the limit for your household size, you may not qualify for free medication through the NPAF. However, you should not assume you are automatically disqualified. Income thresholds can occasionally be reviewed on a case-by-case basis, and there may be other assistance options available to you — including the Leqvio savings card for insured patients. It is always worth calling the NPAF directly at (800) 277-2254 to discuss your specific situation before giving up on the program.
---
Insurance Requirements Explained
Your insurance status plays a major role in whether you qualify. Here is how the NPAF handles each common situation:
---
Step-by-Step: How to Apply
Follow these steps to apply for Leqvio through the NPAF:
1. Gather your documents. You will need: a completed and signed NPAF application form, proof of income (prior year tax return, W-2, or three months of pay stubs), and a current prescription order for Leqvio from your doctor.
2. Choose your application method. The NPAF accepts applications in multiple ways:
- Online: Visit https://www.novartis.com/us-en/patients-and-caregivers/patient-assistance/novartis-patient-assistance-foundation-inc to access the application portal.
- Phone: Call (800) 277-2254 to speak with a program representative who can walk you through the process.
- Fax: Submit your completed application and supporting documents by fax to (888) 891-4924.
3. Have your prescriber sign the application. Most patient assistance applications require both patient and physician signatures. Coordinate with your doctor's office early to avoid delays.
4. Submit everything together. Incomplete applications are a common reason for delays. Double-check that all documents are included before submitting.
5. Wait for confirmation. After submission, the NPAF will review your application and contact you or your prescriber's office with a decision.
6. For more program details, visit https://www.leqvio.com/support at any time.
---
What to Expect: Timeline and Delivery
Most applications are processed within 2 to 5 business days after the NPAF receives a complete submission. If your application is approved, the NPAF will notify your prescriber's office. Leqvio is shipped directly to your prescriber — not to your home — because it is an injectable medication that must be administered in a clinical setting. You do not need to arrange pickup on your own; your doctor's office will contact you to schedule your injection appointment. Keep in mind that the NPAF requires annual reauthorization. Before your approval year ends, you will need to reapply and provide updated income documentation to continue receiving the medication.
---
Alternatives If You Don't Qualify
If you do not qualify for the NPAF, there are still other options to explore:
1. Biosimilars: There are currently no FDA-approved biosimilar alternatives to Leqvio (inclisiran). This is something to revisit over time as the regulatory landscape changes.
2. Manufacturer savings card: If you have commercial insurance, Novartis offers a Leqvio copay card for eligible insured patients. You can enroll at https://www.leqvio.com/copay-card. This will not apply to Medicare or Medicaid patients.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states run their own programs to help residents afford prescription drugs, particularly for seniors and people with disabilities. Search for your state's SPAP through your state health department website.
4. NeedyMeds.org: This free, independent database lists hundreds of patient assistance programs, copay assistance funds, and disease-specific resources. Visit https://www.needymeds.org and search by drug name or condition to find additional options that may fit your situation.
---
*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Novartis. Program terms may change — verify current requirements at [https://www.leqvio.com/support](https://www.leqvio.com/support) before applying.*
---
Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Novartis offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Most complete applications are reviewed within 2 to 5 business days. Make sure all required documents — including your signed application, proof of income, and prescription order — are submitted together to avoid delays.
No. If your application is approved, Leqvio is shipped directly to your prescriber's office. Because it is an injectable medication given in a clinical setting, you will need to schedule an appointment with your doctor to receive it.
Yes, Medicare Part D beneficiaries may qualify if they can demonstrate financial hardship. Unlike many programs that exclude Medicare patients entirely, the NPAF has provisions for Part D enrollees who struggle to afford their medication.
Yes. The NPAF requires annual reauthorization. Before your current approval period ends, you will need to submit an updated application with current proof of income to continue receiving Leqvio through the program.
You may still want to contact the NPAF directly at (800) 277-2254. In some cases, applications near the income threshold may be reviewed individually. You can also explore the Leqvio copay savings card if you have commercial insurance, or check NeedyMeds.org for other assistance programs.
Ready to Apply for Leqvio Assistance?
RX Advantages handles the entire Novartis Patient Assistance Foundation (NPAF) application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month