Lorbrena (lorlatinib)
Patient Assistance Program Guide — Pfizer Oncology Together
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured, underinsured, or patients with government insurance (Medicare/Medicaid) who meet medical and financial criteria. Commercially insured patients are eligible for the savings card but may be eligible for PAP if coverage is denied.
Residency
U.S. resident with valid address (including US territories)
Income Limits (500% FPL)
Calculated based on 500% of the 2025 FPL, which is the standard threshold for Pfizer Oncology Together oral medications.
Based on 2025 HHS Federal Poverty Level guidelines.
# Pfizer Oncology Together Patient Assistance Guide: Lorbrena (Lorlatinib)
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Who Qualifies for the Pfizer Oncology Together?
If you have been prescribed Lorbrena (lorlatinib) and are struggling to afford it, you may qualify to receive it at no cost through the Pfizer Oncology Together Patient Assistance Program. This program is designed to help patients who meet certain income and insurance requirements.
To give you a quick sense of the income threshold: if you live alone, your annual household income must be $75,300 or less to potentially qualify. For larger households, the limits are higher.
On the insurance side, you generally need to be uninsured, underinsured, or enrolled in a government insurance program such as Medicare or Medicaid to be eligible for the free medication benefit. Patients with commercial insurance who have been denied coverage may also qualify. If you have commercial insurance with coverage, a co-pay savings card option may be available to you instead.
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About Lorbrena (Lorlatinib)
Lorbrena is a prescription oral medication manufactured by Pfizer. It is approved by the U.S. Food and Drug Administration (FDA) to treat adults with ALK-positive metastatic non-small cell lung cancer (NSCLC). It belongs to a drug class called anaplastic lymphoma kinase (ALK) inhibitors, which work by targeting a specific genetic mutation involved in certain lung cancers.
Because Lorbrena is a targeted specialty medication, it carries a very high list price that can reach tens of thousands of dollars per month without insurance or assistance. This cost puts the medication out of reach for many patients. Programs like Pfizer Oncology Together exist specifically to address this financial barrier and help eligible patients access the medication their doctor has prescribed.
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Income Eligibility: Full Breakdown
Pfizer Oncology Together uses income thresholds set at 500% of the 2025 Federal Poverty Level (FPL) for oral medications like Lorbrena. The limits by household size are:
| Household Size | Max Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Your household includes anyone living with you whose income contributes to shared expenses. If your household is larger than four people, income limits continue to increase — contact the program directly at (877) 744-5675 to ask about your specific situation.
Income is typically verified using your most recent federal tax return (Form 1040), W-2 forms, or three months of recent pay stubs. If your income has recently changed due to job loss or other circumstances, you may be able to document your current income situation rather than relying solely on prior-year records.
If your income is above the listed threshold, you do not automatically qualify for the free medication benefit — but you are not necessarily without options. See the "Alternatives If You Don't Qualify" section below for other resources that may help.
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Insurance Requirements Explained
Your insurance status plays an important role in determining which part of the program applies to you:
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Step-by-Step: How to Apply
Follow these steps to apply for Lorbrena through Pfizer Oncology Together:
1. Gather your documents before you start. You will need: a completed enrollment form (with both your signature and your prescriber's signature), proof of income (most recent Form 1040, W-2, or three months of pay stubs), and a current prescription for Lorbrena.
2. Choose your application method.
3. Have your prescriber involved early. The enrollment form requires your doctor's signature. Many oncology practices are familiar with this program and can help complete the prescriber section.
4. Submit all documents together to avoid processing delays. Incomplete applications are a common reason for slower turnaround.
5. Wait for confirmation. After submission, the program typically processes applications within 2 to 3 business days. You will receive notification of your approval status.
6. If approved, Lorbrena will be shipped directly to your home address. No pickup at a pharmacy is required.
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What to Expect: Timeline and Delivery
Once you submit a complete application, Pfizer Oncology Together typically processes it within 2 to 3 business days. You should receive confirmation of your enrollment status from the program directly. If approved, your Lorbrena will be shipped to your home — you do not need to visit a pharmacy or specialty pharmacy location to pick it up.
Your enrollment is not permanent. Annual reauthorization is required, meaning you will need to reconfirm your eligibility each year. The program will typically notify you when your renewal is approaching. To avoid any gap in your medication supply, start the renewal process as early as possible before your current authorization period ends.
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Alternatives If You Don't Qualify
If you do not meet the eligibility requirements for the PAP, there are still options worth exploring:
1. Biosimilars: There are currently no FDA-approved biosimilar alternatives to Lorbrena. Because it is a small-molecule targeted therapy rather than a biologic, traditional biosimilar substitution does not apply.
2. Co-pay savings card (commercially insured patients): If you have private insurance that covers Lorbrena, you may qualify for the Pfizer Oncology Together Co-Pay Savings Program, which can reduce your out-of-pocket costs. Learn more at https://www.lorbrena.com/pfizer-oncology-together-co-pay-savings-program.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer their own prescription assistance programs, particularly for Medicare beneficiaries. Eligibility and benefits vary by state. Your state health department or insurance counseling office (often called SHIP) can provide guidance.
4. NeedyMeds.org: This free, nonprofit database at https://www.needymeds.org lists hundreds of patient assistance programs, co-pay assistance options, and disease-specific foundations. It is a useful starting point if you are exploring every available resource.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Pfizer. Program terms may change — verify current requirements at [https://www.lorbrena.com/support](https://www.lorbrena.com/support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Pfizer offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Once Pfizer Oncology Together receives your complete application — including your enrollment form, income documents, and prescription — processing typically takes 2 to 3 business days. After approval, your medication is shipped directly to your home. Delays can occur if any documents are missing, so make sure to submit everything together.
Yes, Medicare patients may be eligible for the Pfizer Oncology Together Patient Assistance Program if they meet the income and medical criteria. Because federal law prevents Medicare beneficiaries from using most manufacturer co-pay cards, the PAP is typically the main option available. Call (877) 744-5675 to discuss your specific situation.
If your income exceeds the threshold, you may not qualify for the free medication benefit under the standard PAP. However, it is still worth calling the program at (877) 744-5675 to explain your circumstances. You may also want to explore the co-pay savings card if you have commercial insurance, or check NeedyMeds.org and your state pharmaceutical assistance program for additional help.
Yes. Pfizer Oncology Together requires annual reauthorization. Your eligibility is reviewed each year to confirm you still meet the income, insurance, and medical criteria. The program will typically notify you before your current enrollment period ends. Starting the renewal process early helps prevent any gap in your medication supply.
Yes. The enrollment form requires both your signature and your prescriber's signature, and it must be completed for each application or renewal. Even if your doctor has your records on file, a freshly signed enrollment form is required by the program. Many oncology offices are familiar with Pfizer Oncology Together and can complete their portion quickly.
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