Lumakras (sotorasib)
Patient Assistance Program Guide — Amgen Safety Net Foundation
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured, underinsured, or Medicare Part D patients who meet financial criteria; patients with commercial insurance are redirected to the Co-Pay program.
Residency
U.S. resident or U.S. territory resident with a valid address
Income Limits (500% FPL)
Calculated based on 500% of 2025 FPL which is the standard threshold for Amgen oncology specialty programs.
Based on 2025 HHS Federal Poverty Level guidelines.
# Lumakras (Sotorasib) Patient Assistance Guide: Amgen Safety Net Foundation
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Who Qualifies for the Amgen Safety Net Foundation?
If you have been prescribed Lumakras (sotorasib) and cannot afford it, the Amgen Safety Net Foundation may be able to provide it to you at no cost. This program is designed for patients who are uninsured, underinsured, or enrolled in Medicare Part D and who meet certain financial criteria. For a single-person household, your annual income must be $75,300 or less to potentially qualify. If you have commercial (private) insurance, you will not be directed to this program — instead, Amgen offers a separate Co-Pay Assistance Program for insured patients. Meeting income and insurance requirements does not guarantee approval, but many patients who apply with complete documentation receive a decision within one to two business days.
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About Lumakras (Sotorasib)
Lumakras (sotorasib) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with non-small cell lung cancer (NSCLC) whose tumors have a specific genetic change called a KRAS G12C mutation. It belongs to a drug class known as KRAS G12C inhibitors. Lumakras is a targeted oral therapy, meaning it is taken by mouth in tablet form. Without insurance or financial assistance, the cost of Lumakras can be extremely high — often tens of thousands of dollars per month — placing it out of reach for many patients. Patient assistance programs like the Amgen Safety Net Foundation exist to help close that gap for those who qualify.
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Income Eligibility: Full Breakdown
The Amgen Safety Net Foundation uses income thresholds based on 500% of the 2025 Federal Poverty Level (FPL), which is the standard Amgen applies to its oncology specialty programs. Here is what the limits look like by household size:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Your income is typically verified using your most recent federal tax return, W-2 forms, or three months of recent pay stubs. Amgen generally looks at your prior year's reported income, though current-year documentation may be accepted in some circumstances — for example, if your income has recently changed due to job loss or retirement.
If your household size is larger than four people, you may still qualify. Larger household sizes correspond to higher income thresholds under the FPL scale, so it is worth applying even if your income appears to exceed the figures listed above.
If your income is above the limit for your household size, you may not qualify for this program. In that case, see the "Alternatives If You Don't Qualify" section below for other options that may still help reduce your costs.
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Insurance Requirements Explained
Your insurance status plays an important role in determining which Amgen program you are directed to. Here is a straightforward breakdown:
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Step-by-Step: How to Apply
Step 1: Gather your documents.
Before you start, collect the following: your most recent federal tax return, W-2, or three months of pay stubs; a valid prescription for Lumakras from your doctor; and your insurance card (if you have insurance of any kind).
Step 2: Choose your application method.
You have several options:
Step 3: Have your prescriber involved.
Your doctor or their office staff will need to sign off on portions of the application. Many prescriber offices are familiar with this process and can assist. Consider calling your oncology nurse or care coordinator to help coordinate submission.
Step 4: Submit and confirm receipt.
After submitting, confirm that your application and all documents were received, especially if you faxed them. Missing documents are the most common cause of delays.
Step 5: Wait for a decision.
Most completed applications are reviewed within one to two business days. You or your prescriber's office will be notified of the outcome.
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What to Expect: Timeline and Delivery
Once your application is approved, Lumakras will be shipped directly to your home address — you do not need to pick it up at a pharmacy. Shipping timelines may vary, so contact the program at (866) 264-2778 if you have not received a shipment notification within a few business days of approval.
Your approval is not permanent. The Amgen Safety Net Foundation requires annual reauthorization, meaning you will need to reapply and reconfirm your eligibility once per year. Watch for communication from Amgen as your renewal date approaches so your medication supply is not interrupted.
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Alternatives If You Don't Qualify
If you do not meet the Amgen Safety Net Foundation's criteria, you still have options worth exploring.
Biosimilars: There are currently no FDA-approved biosimilar alternatives to Lumakras. Sotorasib is a first-in-class targeted therapy, and no generic or biosimilar version is available at this time.
Manufacturer Co-Pay Card (insured patients): If you have commercial insurance, Amgen offers a Co-Pay Assistance Program that can help reduce your out-of-pocket costs. You can enroll at https://www.amgensupportplus.com/lumakras/copay.
State Pharmaceutical Assistance Programs (SPAPs): Many states offer programs that help residents pay for high-cost medications, particularly for older adults or those with disabilities. Eligibility and benefits vary by state. Ask your doctor's office or a hospital social worker to help you identify what is available in your state.
NeedyMeds.org: This free, nonprofit database allows you to search for additional assistance programs by drug name or diagnosis. Visit https://www.needymeds.org to explore other resources that may apply to your situation.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Amgen. Program terms may change — verify current requirements at [https://www.lumakras.com/support](https://www.lumakras.com/support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Amgen offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Yes. Medicare Part D patients who meet the income requirements may apply to the Amgen Safety Net Foundation. This is different from many manufacturer programs, which exclude Medicare patients. Call (866) 264-2778 to confirm your eligibility before applying.
Most completed applications are reviewed within one to two business days. Incomplete applications — missing documents like proof of income or a valid prescription — can slow down the process. Make sure all materials are submitted together to avoid delays.
Yes. The Amgen Safety Net Foundation requires annual reauthorization. You will need to reconfirm your income and insurance status each year to continue receiving Lumakras through the program. Watch for renewal notices from Amgen so your medication is not interrupted.
You may still be worth applying, especially if your household size is larger than four people, since the income threshold increases with household size. If you are above the limit, the Co-Pay Assistance Program or state pharmaceutical assistance programs may provide an alternative path to savings.
If you are approved through the Amgen Safety Net Foundation, Lumakras is shipped directly to your home. You do not need to visit a pharmacy or your doctor's office to receive it. Contact the program at (866) 264-2778 if you have questions about your shipment.
Ready to Apply for Lumakras Assistance?
RX Advantages handles the entire Amgen Safety Net Foundation application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month