Mayzent (siponimod)
Patient Assistance Program Guide — Novartis Patient Assistance Foundation (NPAF)
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Available to uninsured patients or those with limited/no prescription coverage. Medicare Part D patients may qualify if they have been denied LIS and meet specific financial hardship criteria.
Residency
U.S. resident, citizen, or legal alien with a valid U.S. address
Income Limits (500% FPL)
Threshold is calculated at 500% of the 2025 FPL for specialty neurology products.
Based on 2025 HHS Federal Poverty Level guidelines.
# Getting Mayzent (Siponimod) Through the Novartis Patient Assistance Foundation (NPAF): A Complete Guide from RX Advantages
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Who Qualifies for the Novartis Patient Assistance Foundation (NPAF)?
If you need Mayzent (siponimod) and cannot afford it, the Novartis Patient Assistance Foundation (NPAF) may be able to provide it to you at no cost. This program is designed specifically for patients who lack adequate prescription coverage and meet income requirements. For a single person, the maximum annual income to qualify is $75,300. In general, you must be uninsured or have limited prescription drug coverage to be eligible — patients with full drug coverage through commercial insurance or Medicaid typically do not qualify. If you meet these basic criteria, the NPAF may be a strong option to help you access this medication without paying out of pocket.
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About Mayzent (Siponimod)
Mayzent (siponimod) is a prescription medication approved by the FDA to treat relapsing forms of multiple sclerosis (MS). This includes Clinically Isolated Syndrome (CIS), Relapsing-Remitting Multiple Sclerosis (RRMS), and Active Secondary Progressive Multiple Sclerosis (SPMS). It belongs to a drug class called sphingosine 1-phosphate (S1P) receptor modulators, which work by targeting specific receptors involved in the immune response. As a specialty neurology medication, Mayzent carries a high list price that can make it difficult or impossible to afford without insurance or assistance. There are currently no FDA-approved generic or biosimilar versions of Mayzent available, which means the brand-name medication is the only option for patients at this time.
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Income Eligibility: Full Breakdown
The NPAF uses income thresholds set at 500% of the 2025 Federal Poverty Level (FPL) for specialty neurology products like Mayzent. Your entire household's gross annual income is considered, not just your personal earnings. The limits by household size are:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Income is typically verified using your most recent federal tax return (Form 1040), W-2 forms, or three months of recent pay stubs. If your household size is larger than four people, the income threshold increases with each additional member — contact the NPAF directly at (800) 277-2254 to ask about your specific situation.
If your income is above these limits, you may not qualify for free medication through NPAF. However, do not stop there. Review the Alternatives section below for other options that may still help reduce your costs. Income limits are reviewed annually, and the program requires reauthorization each year, so your eligibility could change if your financial situation changes.
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Insurance Requirements Explained
Your current insurance status plays a major role in whether you qualify for the NPAF. Here is how the program typically applies to different situations:
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Step-by-Step: How to Apply
Follow these steps to apply for Mayzent through the NPAF:
1. Gather your documents. You will need: a completed and signed NPAF application, proof of income (your most recent Form 1040, W-2, or three months of pay stubs), and a valid prescription for Mayzent from your doctor.
2. Get your prescription ready. Your prescribing physician must be involved in the application. Make sure your prescription is current and includes the correct dosage.
3. Choose your application method. You have three options:
- Online: Visit https://www.patientassistance.novartis.com/ to complete the application electronically.
- Phone: Call (800) 277-2254 to apply with assistance or ask questions before applying.
- Fax: Fax your completed paper application and supporting documents to (888) 891-4924.
4. Submit all required documents together. Incomplete applications slow down the review process. Double-check that everything is signed and included before submitting.
5. Wait for your review. The NPAF typically completes its initial review within two business days of receiving a complete application.
6. Watch for approval confirmation. You or your doctor's office will be notified of the decision. If approved, your medication will be arranged for shipment.
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What to Expect: Timeline and Delivery
Once you submit a complete application, NPAF typically reviews it within two business days. After approval, Mayzent is shipped directly to your home address — you do not need to go to a pharmacy or your doctor's office to pick it up. There is nothing additional required from you at the point of delivery beyond being available to receive the shipment.
Your approval is valid for one year. Before that period ends, you will need to reauthorize your enrollment by submitting updated income documentation and a renewed prescription. NPAF may send you a reminder, but it is a good idea to track your renewal date yourself to avoid any gap in your medication supply.
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Alternatives If You Don't Qualify
If you do not meet the NPAF's requirements, there are other options to explore:
1. Biosimilars: There are currently no FDA-approved biosimilar or generic versions of Mayzent (siponimod). This means no lower-cost alternatives in this specific drug class are available at this time.
2. Manufacturer savings card (for insured patients): If you have commercial insurance, Novartis offers a co-pay support program for Mayzent. Visit https://www.mayzent.com/financial-support/co-pay-support to learn more and enroll. This will not apply to Medicare or Medicaid patients.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer programs to help residents with high drug costs, particularly for chronic conditions like MS. Search for your state's SPAP through your state health department's website.
4. NeedyMeds.org: This free, independent database at www.needymeds.org lists hundreds of assistance programs by drug name, condition, and state. It is a helpful resource if you are exploring all your options and want a broader picture of what may be available to you.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Novartis. Program terms may change — verify current requirements at [https://www.mayzent.com/support](https://www.mayzent.com/support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Novartis offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
The NPAF typically completes its review within two business days of receiving a complete application. To avoid delays, make sure you submit all required documents — including your signed application, proof of income, and a valid prescription — at the same time.
Possibly, but only under specific conditions. You must have been formally denied the Low Income Subsidy (LIS) through Medicare and be able to demonstrate financial hardship. Most standard Medicare Part D enrollees do not qualify. Call (800) 277-2254 to discuss your specific situation before applying.
Yes. A valid prescription for Mayzent from your prescribing physician is required as part of the application. Your doctor may also need to sign portions of the application form. It is a good idea to let your doctor's office know you are applying so they can assist you with any required paperwork.
You will need to reauthorize your enrollment annually. This means submitting updated proof of income and a renewed prescription before your current approval expires. It is best to start this process a few weeks early to prevent any interruption in your medication supply.
If your income exceeds the NPAF thresholds, you may still have options. If you have commercial insurance, Novartis offers a co-pay savings card at https://www.mayzent.com/financial-support/co-pay-support. You can also check NeedyMeds.org or your state's pharmaceutical assistance program for additional support.
Ready to Apply for Mayzent Assistance?
RX Advantages handles the entire Novartis Patient Assistance Foundation (NPAF) application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month