Onpattro (patisiran)

Do You Qualify?

Income Limits (500% FPL)

Alnylam Assist uses a 500% FPL threshold for most patients; cases are reviewed individually for financial hardship.

Based on 2025 HHS Federal Poverty Level guidelines.

# Getting Onpattro (Patisiran) Through the Alnylam Assist Program

Who Qualifies for the Alnylam Assist?

If you have been prescribed Onpattro (patisiran) and cannot afford it, you may be able to get it at little or no cost through Alnylam Assist, the patient assistance program offered directly by Alnylam Pharmaceuticals. For a single-person household, the maximum annual income to qualify is $75,300. Patients who are uninsured, underinsured, or enrolled in Medicare Part B or Part D may be eligible if they meet financial criteria. Even if your income is above the standard limit, Alnylam reviews cases individually for financial hardship, so it may still be worth applying. RX Advantages can help you understand your options before you start the process.

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About Onpattro (Patisiran)

Onpattro (patisiran) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat polyneuropathy caused by hereditary transthyretin-mediated (hATTR) amyloidosis in adults. It belongs to a class of drugs called small interfering RNA (siRNA) therapies, which work by targeting a specific genetic process involved in the disease. Onpattro is administered by intravenous infusion, typically in a clinical setting. Because it is a complex, specialty biologic medication, its list price is extremely high — often several hundred thousand dollars per year — making it out of reach for many patients without financial assistance. No FDA-approved biosimilar versions are currently available.

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Income Eligibility: Full Breakdown

Alnylam Assist uses an income threshold set at approximately 500% of the Federal Poverty Level (FPL). The chart below shows the maximum annual household income allowed for common household sizes:

| Household Size | Max Annual Income |

|---|---|

| 1 person | $75,300 |

| 2 persons | $102,200 |

| 3 persons | $129,100 |

| 4 persons | $156,000 |

To verify your income, you will typically need to provide your most recent federal tax return or a W-2 form. If your income has changed recently, three months of pay stubs may also be accepted. Your household size includes everyone in your home whose income contributes to shared expenses.

If your income is above these limits, do not assume you are automatically disqualified. Alnylam reviews applications on a case-by-case basis and may consider financial hardship circumstances — such as high out-of-pocket medical costs or recent changes in employment — when making eligibility decisions. It is always worth submitting an application and explaining your situation honestly in writing.

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Insurance Requirements Explained

Your insurance status plays a key role in how Alnylam Assist can help you. Here is a simple breakdown:

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Step-by-Step: How to Apply

Step 1 — Gather your documents. Before you start, collect the following: a signed Alnylam Assist Patient Start Form (available online or from your prescriber), proof of income such as your most recent tax return or W-2, your insurance card or cards if you have coverage, and a valid prescription for Onpattro.

Step 2 — Choose how you want to apply. You have three options:

Step 3 — Complete the Patient Start Form. This form must be signed by both you and your prescribing physician. Your doctor's office can help complete the clinical sections.

Step 4 — Submit everything together. Incomplete applications take longer to process. Make sure all required documents are included before submitting.

Step 5 — Wait for a decision. Processing typically takes 7 to 10 business days from the date Alnylam receives your complete application.

Step 6 — Your prescriber is notified. If approved, Alnylam will contact your prescriber's office directly.

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What to Expect: Timeline and Delivery

After you submit a complete application, Alnylam Assist typically processes it within 7 to 10 business days. You will not need to do anything additional during this time unless Alnylam contacts you to request more information. If approved, Onpattro is shipped directly to your prescriber's office or infusion center — not to your home. Because Onpattro requires intravenous administration in a clinical setting, your prescriber's staff will coordinate the infusion schedule with you. You do not need to pick up or transport the medication yourself. Approval through Alnylam Assist is not permanent. You will need to reauthorize your enrollment once per year to continue receiving the medication at no or reduced cost.

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Alternatives If You Don't Qualify

If you do not qualify for Alnylam Assist, there are still options to explore.

Biosimilars: There are currently no FDA-approved biosimilar versions of Onpattro, so this is not an available cost-saving option at this time.

Manufacturer savings card: If you have commercial (private) insurance, Alnylam offers a separate savings card program for insured patients. Visit https://www.alnylamassist.com/onpattro/patient-support/financial-assistance to see if you may qualify for copay support.

State Pharmaceutical Assistance Programs (SPAPs): Many states operate their own drug assistance programs, particularly for seniors and people with disabilities. Eligibility and benefits vary by state. Your state health department's website is a good starting point.

NeedyMeds.org: This free, independent database at https://www.needymeds.org lists patient assistance programs, disease-specific funds, and other resources that may help cover your medication costs. It is a useful tool regardless of your insurance status.

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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Alnylam. Program terms may change — verify current requirements at [https://www.alnylam.com/patient-support-programs](https://www.alnylam.com/patient-support-programs) before applying.*

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