Oxlumo (lumasiran)
Patient Assistance Program Guide — Alnylam Assist
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured, underinsured, or patients with commercial insurance (via copay program). Medicare patients may be eligible based on specific financial criteria.
Residency
Must be a resident of the U.S. or its territories and be under the care of a U.S. physician.
Income Limits (500% FPL)
Calculated at 500% FPL based on common high-cost rare disease program standards; Alnylam Assist evaluates on a case-by-case basis.
Based on 2025 HHS Federal Poverty Level guidelines.
# Alnylam Assist Patient Assistance Program for Oxlumo (Lumasiran): A Complete Guide
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Who Qualifies for the Alnylam Assist?
If you have been prescribed Oxlumo (lumasiran) for primary hyperoxaluria type 1 (PH1), you may be able to get your medication at little or no cost through the Alnylam Assist program. Single-person households with an annual income at or below $75,300 may qualify for free or reduced-cost medication. Patients with two, three, or four people in their household may qualify at higher income thresholds. The program is open to patients who are uninsured, underinsured, or covered by commercial insurance. Medicare patients may also be eligible depending on their specific financial situation. Alnylam reviews each application individually, so even if you are unsure whether you qualify, it is worth applying. RX Advantages encourages you to contact the program directly to confirm your eligibility before assuming you do not meet the requirements.
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About Oxlumo (Lumasiran)
Oxlumo (lumasiran) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat primary hyperoxaluria type 1 (PH1), a rare genetic disorder affecting the kidneys and urinary system. It belongs to a class of medicines called small interfering RNA (siRNA) therapeutics, which work at the genetic level to target specific processes in the body. Because Oxlumo is a first-in-class therapy for a rare condition, it carries a very high list price — often tens of thousands of dollars per dose — making it financially out of reach for many patients without assistance. There are currently no FDA-approved biosimilar versions of Oxlumo available, which means the brand-name product is the only option on the market.
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Income Eligibility: Full Breakdown
The Alnylam Assist program uses income thresholds based on your household size to determine whether you qualify for free or reduced-cost Oxlumo. The following limits apply:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
These figures are estimated at 500% of the Federal Poverty Level (FPL), which is a common standard used by high-cost rare disease programs. Alnylam evaluates applications on a case-by-case basis, so patients whose income is slightly above these limits may still be considered.
To verify your income, you will typically need to provide your most recent federal tax return, a W-2 form, or three months of recent pay stubs. If your income situation has changed — for example, due to job loss or a reduction in hours — you may be able to use current pay stubs rather than last year's tax return to reflect your actual financial situation. Households larger than four people should contact the program directly, as additional flexibility may apply.
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Insurance Requirements Explained
Your insurance status affects how Alnylam Assist can help you. Here is a straightforward breakdown:
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Step-by-Step: How to Apply
Follow these steps to apply for Alnylam Assist:
1. Gather your documents before you start. You will need: a completed and signed Alnylam Assist Patient Enrollment Form, a valid prescription for Oxlumo from your doctor, and proof of household income (most recent tax return, W-2, or three months of pay stubs).
2. Choose your application method. You can apply online, by phone, or by fax.
- Online: Visit https://www.alnylamassist.com/ to complete and submit your enrollment form electronically.
- Phone: Call (833) 256-2744 to speak with a program representative who can guide you through the process.
- Fax: Send completed documents to (833) 256-2746.
3. Have your prescriber involved. Your doctor or their office will likely need to sign the enrollment form and confirm the prescription. Many offices handle this regularly, so ask your care team for help.
4. Submit all required documents together. Incomplete applications take longer to process. Double-check that everything is signed and all income documentation is included.
5. Wait for confirmation. After submission, the program will review your application. Processing typically takes 3 to 5 business days, though timelines may vary.
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What to Expect: Timeline and Delivery
After your application is submitted, processing typically takes 3 to 5 business days. You will receive confirmation of your approval status from the Alnylam Assist program. If approved, your Oxlumo will be shipped directly to your prescriber's office rather than to your home. Your doctor's office will contact you to schedule administration. You do not need to pick up or manage the medication yourself. Reauthorization is required once per year, so you will need to renew your enrollment to continue receiving assistance. The program may contact you or your prescriber in advance of the renewal deadline, but it is a good idea to track this yourself to avoid a gap in coverage.
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Alternatives If You Don't Qualify
If you do not qualify for the Alnylam Assist patient assistance program, there are still options worth exploring:
1. Biosimilars: There are currently no FDA-approved biosimilar versions of Oxlumo available, so this option does not apply at this time.
2. Manufacturer savings card: If you have commercial (private) insurance, Alnylam offers a savings card program that may reduce your copay or out-of-pocket costs. Visit https://www.alnylamassist.com/oxlumo/financial-assistance to learn more and enroll.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer programs to help residents pay for high-cost medications. Eligibility and benefits vary by state. Contact your state health department or visit your state's official health website to find out what is available where you live.
4. NeedyMeds.org: This free online database at https://www.needymeds.org lists hundreds of patient assistance programs, copay cards, and disease-specific funds. It is a useful starting point if you are exploring multiple options at once.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Alnylam. Program terms may change — verify current requirements at [https://www.alnylam.com/patient-support-programs](https://www.alnylam.com/patient-support-programs) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Alnylam offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Processing typically takes 3 to 5 business days after Alnylam receives your completed application. Make sure all required documents — including your signed enrollment form, prescription, and income verification — are submitted together to avoid delays.
No. If your application is approved, Oxlumo will be shipped directly to your prescriber's office. Your doctor's team will contact you to arrange the next steps for receiving your medication.
Yes. The Alnylam Assist program requires annual reauthorization. You will need to renew your enrollment once per year to continue receiving free or reduced-cost medication. It is a good idea to track your renewal date so there is no gap in your supply.
Possibly. Most manufacturer assistance programs do not cover Medicare patients, but Alnylam Assist may review Medicare applications based on specific financial circumstances. Call (833) 256-2744 to speak with a program representative about your situation before assuming you do not qualify.
Alnylam evaluates applications on a case-by-case basis. If your income is close to but slightly above the listed threshold, you may still be considered. Contact the program directly at (833) 256-2744 or visit https://www.alnylamassist.com/ to ask about your specific situation.
Ready to Apply for Oxlumo Assistance?
RX Advantages handles the entire Alnylam Assist application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month