Pemazyre (pemigatinib)

Do You Qualify?

Income Limits (600% FPL)

Income threshold is typically 600% of the FPL for Incyte oncology programs; 2025 calculations applied.

Based on 2025 HHS Federal Poverty Level guidelines.

# IncyteCARES Patient Assistance Program for Pemazyre (pemigatinib): A Complete Guide

Who Qualifies for the IncyteCARES (Connect to Access, Reimbursement, and Education Support)?

If you have been prescribed Pemazyre (pemigatinib) and are struggling to afford it, the IncyteCARES program may be able to provide it at little or no cost. This program is run directly by Incyte, the company that makes Pemazyre. To give you a quick baseline: if you are a single person earning up to $90,360 per year, you may meet the income requirement. On the insurance side, you generally need to be uninsured, underinsured, or have had your coverage denied — though Medicare patients facing financial hardship may also qualify under certain conditions. Reading through this guide will help you understand exactly where you stand and how to move forward.

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About Pemazyre (pemigatinib)

Pemazyre (pemigatinib) is an oral prescription medication made by Incyte. It belongs to a class of drugs called kinase inhibitors, specifically FGFR (fibroblast growth factor receptor) inhibitors. The FDA has approved Pemazyre for adults with certain types of cholangiocarcinoma (a bile duct cancer) that have a specific FGFR2 fusion or rearrangement, as well as for adults and children with myeloid/lymphoid neoplasms (MLN) that have an FGFR1 rearrangement. Because Pemazyre is a targeted specialty cancer drug, its list price can reach tens of thousands of dollars per month without insurance or assistance. There are currently no FDA-approved biosimilar versions of Pemazyre, which means lower-cost generic alternatives are not yet available.

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Income Eligibility: Full Breakdown

The IncyteCARES program uses income thresholds set at approximately 600% of the Federal Poverty Level (FPL). The table below shows the maximum annual household income allowed based on household size, using 2025 calculations:

| Household Size | Max Annual Income |

|---|---|

| 1 person | $90,360 |

| 2 persons | $122,640 |

| 3 persons | $154,920 |

| 4 persons | $187,200 |

For households larger than four people, the income limit typically continues to increase. If your household size is not listed, contact IncyteCARES directly at (855) 472-4377 to ask about your specific situation.

Income is generally verified using your most recent federal tax return, your last W-2, or three months of recent pay stubs. If your income has changed significantly since last year — for example, due to job loss or a major medical expense — you may be able to document your current situation instead.

If your income is above these limits, do not stop reading. The next sections cover savings cards and other programs that may still help you reduce your costs.

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Insurance Requirements Explained

Your current insurance status plays a major role in whether you qualify. Here is how different situations are typically handled:

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Step-by-Step: How to Apply

Follow these steps to apply for Pemazyre through the IncyteCARES program:

1. Gather your documents before you start. You will need: a completed application form with signatures from both you and your prescribing physician, proof of income (your most recent tax return, W-2, or three months of pay stubs), and a valid prescription for Pemazyre.

2. Choose how you want to apply. You have three options:

- Online: Visit https://www.incytecares.com/pemazyre/ to start a digital application.

- By phone: Call (855) 472-4377. A program specialist can walk you through the process and answer questions.

- By fax: Complete a paper application and fax it with your supporting documents to (855) 525-7156.

3. Have your doctor's office involved early. Your physician must sign the application. Many doctor's offices are familiar with this process, but it helps to give them advance notice so they can prepare their portion quickly.

4. Submit all documents together. Incomplete applications take longer to process. Make sure all required items — application, income proof, and prescription — are included in the same submission.

5. Wait for a decision. Processing typically takes 2 to 5 business days after a complete application is received.

6. Confirm your approval and next steps. Once approved, IncyteCARES will contact you or your doctor's office with instructions on receiving your medication.

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What to Expect: Timeline and Delivery

After you submit a complete application, you can generally expect a decision within 2 to 5 business days. Approval notification typically comes through IncyteCARES directly, either to you or to your physician's office. If approved, Pemazyre is shipped directly to your home, so you do not need to pick it up at a pharmacy or your doctor's office. There is nothing you need to do at delivery other than be available to receive the package. Enrollment in the program is not permanent — you will need to reapply and requalify once per year. IncyteCARES may send a reminder when your reauthorization period approaches, but it is a good idea to track your enrollment date yourself so you do not experience a gap in medication.

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Alternatives If You Don't Qualify

If you do not meet the requirements for the free medication program, you still have options:

1. Biosimilars: There are currently no FDA-approved biosimilars for Pemazyre, so this is not yet an available cost-saving option.

2. Savings card for insured patients: If you have commercial insurance, Incyte offers a savings card that may reduce your out-of-pocket costs. You can enroll at https://www.incytecares.com/pemazyre/savings-and-support. This option is not available for Medicare or Medicaid beneficiaries.

3. State Pharmaceutical Assistance Programs (SPAPs): Many states run their own drug assistance programs, especially for older adults or people with disabilities. Your state health department website is a good place to start.

4. NeedyMeds.org: This free, independent database lists hundreds of assistance programs by drug name and condition. Visit www.NeedyMeds.org and search for Pemazyre to see what additional options may apply to you.

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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Incyte. Program terms may change — verify current requirements at [https://www.pemazyre.com/support](https://www.pemazyre.com/support) before applying.*

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