Prolia (denosumab)
Patient Assistance Program Guide — Amgen Safety Net Foundation
Do You Qualify?
Income
Up to $60,240 for a single person
Insurance
Uninsured, underinsured, or Medicare patients who meet specific criteria and lack secondary coverage.
Residency
U.S. resident or resident of U.S. territories
Income Limits (400% FPL)
Calculated based on 400% of the 2025 FPL. Thresholds may vary based on specific drug cost and cost-of-living adjustments in certain states.
Based on 2025 HHS Federal Poverty Level guidelines.
# Getting Prolia (Denosumab) at No Cost Through the Amgen Safety Net Foundation
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Who Qualifies for the Amgen Safety Net Foundation?
If you need Prolia (denosumab) and cannot afford it, you may be able to get it at no cost through the Amgen Safety Net Foundation. This program is designed specifically for patients who are uninsured, underinsured, or on Medicare and struggling to cover the cost of their medication. If you are a single-person household, your annual income must be at or below $60,240 to qualify. Patients with Medicaid or other full government coverage that pays for Prolia are generally not eligible. If you meet the income and insurance requirements, you may qualify to receive Prolia free of charge, shipped directly to your prescribing doctor's office.
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About Prolia (Denosumab)
Prolia is an injectable prescription medication manufactured by Amgen. It belongs to a drug class called RANK ligand (RANKL) inhibitors. It is FDA-approved to treat postmenopausal osteoporosis, bone loss in men receiving treatment for prostate cancer, bone loss in women receiving treatment for breast cancer, and glucocorticoid-induced osteoporosis. Prolia is given as an injection twice a year, typically in a doctor's office. Without insurance or assistance, Prolia can cost well over $1,000 per injection, making it unaffordable for many patients. The Amgen Safety Net Foundation exists to help bridge that cost gap for eligible individuals.
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Income Eligibility: Full Breakdown
The Amgen Safety Net Foundation uses income thresholds based on 400% of the 2025 Federal Poverty Level (FPL). Your household size determines the maximum income allowed.
| Household Size | Max Annual Income |
|---|---|
| 1 person | $60,240 |
| 2 persons | $81,760 |
| 3 persons | $103,280 |
| 4 persons | $124,800 |
Income is typically verified using your most recent federal tax return, your last three months of pay stubs, or a W-2 form. If your income is slightly above the limit, it is still worth calling the program directly at (888) 762-6436 — in some cases, adjustments may apply based on specific drug costs or cost-of-living differences in certain states.
If your household is larger than four people, the income limit generally increases for each additional person. Ask a program representative for the exact figure that applies to your situation. If your income clearly exceeds the threshold and no exception applies, the sections below on alternatives can help you find other options.
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Insurance Requirements Explained
Your current insurance status plays a major role in whether you qualify. Here is how each situation is handled:
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Step-by-Step: How to Apply
Follow these steps to apply for free Prolia through the Amgen Safety Net Foundation:
1. Gather your documents before you start. You will need a completed and signed application form, proof of income (tax return, W-2, or three months of pay stubs), and a valid prescription for Prolia from your doctor.
2. Choose your application method. You can apply online at https://www.amgensafetynetfoundation.com/, by phone at (888) 762-6436, or by fax at (866) 549-7239. Many patients find it easiest to apply online, but phone applications allow you to ask questions in real time.
3. Complete the application form. The form requires your personal information, household size, income details, insurance information, and your prescribing doctor's information. Your doctor or their office staff may need to complete a section of the form.
4. Submit your documents. Upload or fax your proof of income along with the completed application. Make sure all signatures are included — incomplete applications can cause delays.
5. Confirm receipt. After submitting, follow up by phone to confirm your application was received and is being processed.
6. Wait for a decision. Processing typically takes 7–10 business days after your complete application is received.
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What to Expect: Timeline and Delivery
Once your application is approved, you will typically receive confirmation within 7–10 business days. The program will notify you or your doctor's office of the approval. Prolia is shipped directly to your prescribing doctor's office — not to your home. You do not need to pick up or fill a prescription at a pharmacy. Your doctor's staff will contact you to schedule your injection appointment once the medication arrives.
Enrollment in the program is not permanent. You will need to reauthorize annually to continue receiving Prolia at no cost. Watch for renewal notices and begin gathering updated income documents before your current enrollment period ends to avoid any gap in your medication supply.
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Alternatives If You Don't Qualify
If you do not qualify for the Amgen Safety Net Foundation, you still have options worth exploring:
1. Biosimilar medications: Prolia has a biosimilar alternative called Jubbonti, which may be available at a lower cost. Ask your doctor if a biosimilar is appropriate for your treatment.
2. Manufacturer savings card: If you have commercial (private) insurance, Amgen offers a Prolia co-pay card that may reduce your out-of-pocket costs. You can find details at https://www.prolia.com/prolia-copay-card.
3. State Pharmaceutical Assistance Programs (SPAP): Many states offer their own medication assistance programs for residents who do not qualify for federal programs. Eligibility and benefits vary by state.
4. NeedyMeds.org: This free online database at www.needymeds.org lists hundreds of patient assistance programs and discount options by drug name. It is a useful starting point if you need to explore multiple options at once.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Amgen. Program terms may change — verify current requirements at [https://www.prolia.com/insurance-cost](https://www.prolia.com/insurance-cost) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Biosimilar / Generic Alternatives
FDA-approved alternatives to Prolia: Jubbonti. Ask your prescriber if one of these is clinically appropriate for your condition.
Manufacturer Savings Card (for insured patients)
Amgen offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Processing typically takes 7 to 10 business days after the program receives your complete application. Missing documents or unsigned forms can slow this down, so make sure everything is included before you submit.
No. If you are approved, Prolia is shipped directly to your prescribing doctor's office. Your doctor's staff will contact you to schedule your injection once the medication has arrived.
Yes. The Amgen Safety Net Foundation requires annual reauthorization. You will need to submit updated income documentation and a renewed application each year to continue receiving Prolia at no cost.
Yes, you may still qualify. Medicare alone does not disqualify you. The program is designed to help Medicare patients who lack secondary coverage and meet the income requirements. Call (888) 762-6436 to discuss your specific situation.
It is still worth contacting the program directly at (888) 762-6436. In some cases, adjustments may be made based on specific drug costs or cost-of-living differences in certain states. A program representative can tell you whether any exceptions apply to your situation.
Ready to Apply for Prolia Assistance?
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