How much does RX Advantages cost?

The service fee starts at $49.95/month for one medication, scaling up to $149.95/month for five medications. It covers application preparation, submission, and ongoing refill support. Medications themselves are provided at no cost by manufacturer programs.

Do I qualify for prescription assistance?

Most programs help patients below 200–400% of the Federal Poverty Level who lack adequate insurance coverage. Eligibility depends on income, insurance status, and the specific medications needed.

How long does approval take?

Most programs respond within 4–8 weeks of a complete application. Timelines vary by manufacturer. RX Advantages monitors your status and updates you throughout.

Is RX Advantages affiliated with any drug company?

No. RX Advantages is an independent patient advocacy service. We are not affiliated with any pharmaceutical manufacturer, government agency, or insurance plan.

Hematology

Reblozyl (luspatercept)

Patient Assistance Program Guide — Bristol Myers Squibb Patient Assistance Foundation (BMSPAF)

Verified: February 27, 2026

Bristol Myers Squibb Patient Assistance Foundation (BMSPAF)

Program name

2-day review

Processing time

shipped to prescriber

Medication delivery

$90,360

1-person income limit

Do You Qualify?

Income

Up to $90,360 for a single person

Insurance

Uninsured or underinsured; patients with Medicare Part D may qualify if they meet income requirements and demonstrate financial hardship.

Residency

Must live in the United States, Puerto Rico, or the U.S. Virgin Islands

Apply Through RX Advantages

Income Limits (600% FPL)

Household Size	Max Annual Income
1 person	$90,360
2 persons	$122,640
3 persons	$154,920
4 persons	$187,200

Income threshold for hematology products is typically 600% FPL; amounts calculated based on 2025 HHS guidelines.

Based on 2025 HHS Federal Poverty Level guidelines.

# Reblozyl (Luspatercept) Patient Assistance Guide: Bristol Myers Squibb Patient Assistance Foundation (BMSPAF)

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Who Qualifies for the Bristol Myers Squibb Patient Assistance Foundation (BMSPAF)?

If you need Reblozyl (luspatercept) but cannot afford it, the Bristol Myers Squibb Patient Assistance Foundation (BMSPAF) may be able to provide it at no cost to you. To qualify, you generally need to meet income guidelines — for a single-person household, your annual income must be at or below $90,360. You must also be either uninsured or underinsured, meaning your current coverage does not adequately cover the cost of Reblozyl. Patients with Medicare Part D may also qualify if they meet the income requirements and can show financial hardship. If you are eligible, Reblozyl is shipped directly to your prescriber's office at no charge to you.

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About Reblozyl (Luspatercept)

Reblozyl (luspatercept) is an erythroid maturation agent approved by the U.S. Food and Drug Administration (FDA). It is prescribed for adults with anemia caused by beta thalassemia or lower-risk myelodysplastic syndromes (MDS). These are serious blood conditions that can require ongoing medical management. Reblozyl works by supporting the body's red blood cell production process. Because it is a specialty biologic medication, its list price can run into tens of thousands of dollars per year, placing it out of reach for many patients without strong insurance coverage or financial assistance. There are currently no FDA-approved biosimilar versions of Reblozyl available, which limits lower-cost alternatives.

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Income Eligibility: Full Breakdown

BMSPAF uses income thresholds set at approximately 600% of the Federal Poverty Level (FPL), based on 2025 U.S. Department of Health and Human Services (HHS) guidelines. The limits vary by household size:

| Household Size | Maximum Annual Income |

|---|---|

| 1 person | $90,360 |

| 2 persons | $122,640 |

| 3 persons | $154,920 |

| 4 persons | $187,200 |

For households larger than four people, the income threshold typically increases. Contact BMSPAF directly at (800) 736-0003 to ask about the limit that applies to your household size.

Your income is generally verified using your most recent federal tax return, W-2 forms, or three months of recent pay stubs. If your financial situation has changed since you last filed taxes — for example, due to a job loss or reduction in hours — you may be able to use pay stubs or other documentation to better reflect your current income.

If your income is above the listed limits, you may not qualify for the free medication program. However, you should still explore the other options listed later in this guide, including the Reblozyl savings card for insured patients.

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Insurance Requirements Explained

Your insurance status plays a key role in whether you qualify for BMSPAF. Here is how different situations are handled:

●If you are uninsured: You are likely eligible to apply, provided you meet the income requirements. Being uninsured is one of the clearest paths to qualifying for this program.

●If you have Medicare Part D: You may still qualify. BMSPAF makes exceptions for Medicare Part D beneficiaries who meet the income guidelines and can demonstrate financial hardship. This is notable, as many patient assistance programs exclude Medicare patients entirely.

●If you have private insurance that covers less than 50% of your costs: You may be considered "underinsured" and could qualify. The program evaluates whether your out-of-pocket costs create a financial burden even with your existing coverage.

●If you have Medicaid: Patients with full Medicaid coverage are generally not eligible for manufacturer patient assistance programs, as Medicaid is intended to cover these costs. Contact BMSPAF directly if you have a partial or spend-down Medicaid plan to ask about your specific situation.

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Step-by-Step: How to Apply

1. Check your eligibility first. Review the income table above and confirm your insurance status before you begin. If you are unsure, call BMSPAF at (800) 736-0003 to speak with a representative.

2. Gather your documents. You will need:

- A completed and signed BMSPAF application form

- Proof of income (your most recent federal tax return, W-2, or three months of pay stubs)

- A valid prescription from your licensed healthcare provider

3. Download or request the application. Visit https://www.bmspaf.org to access the online application or to download a printable form. Your prescriber's office may also have forms on hand.

4. Complete the application. Both you and your prescriber will need to sign the application. Your doctor's office can often help coordinate this step.

5. Submit your application. You have several options:

- Online: Submit through https://www.bmspaf.org

- Fax: Send to (888) 776-2370

- Phone: Call (800) 736-0003 for guidance on submitting by mail or for other questions

6. Wait for a decision. BMSPAF typically completes its review within two business days of receiving a complete application.

7. Your prescriber is notified. If approved, BMSPAF will contact your prescriber's office and arrange delivery of your medication.

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What to Expect: Timeline and Delivery

Once BMSPAF receives your complete application — including all required documents and your prescriber's signature — the review process typically takes about two business days. If approved, you will be notified, and Reblozyl will be shipped directly to your prescriber's office. You do not need to pick it up at a pharmacy. Your doctor's office will let you know when the medication has arrived and schedule your treatment accordingly.

Your approval is not permanent. BMSPAF requires annual reauthorization, meaning you will need to reapply each year to confirm that you still meet the income and insurance requirements. Your prescriber's office may help manage this process, but it is a good idea to track your renewal date so your treatment is not interrupted.

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Alternatives If You Don't Qualify

If you do not qualify for BMSPAF, there are still options worth exploring:

1. Biosimilars: There are currently no FDA-approved biosimilar versions of Reblozyl available in the United States. This option is not available at this time.

2. Manufacturer savings card: If you have commercial (private) insurance, Bristol Myers Squibb offers a Reblozyl savings card that may reduce your out-of-pocket costs. Visit https://www.reblozyl.com/patient/support-and-resources for details and to enroll. This option is generally not available to Medicare or Medicaid patients.

3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer their own programs to help residents pay for prescription medications. Eligibility and benefits vary by state. Search for your state's program through your state health department website.

4. NeedyMeds.org: This free, independent database at https://www.needymeds.org lists patient assistance programs, disease-specific foundations, and other resources that may help cover the cost of Reblozyl or related care costs.

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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Bristol Myers Squibb. Program terms may change — verify current requirements at [https://www.bms.com/patient-and-caregiver-support/patient-assistance-foundation.html](https://www.bms.com/patient-and-caregiver-support/patient-assistance-foundation.html) before applying.*

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Documents You'll Need

Completed and signed application form

Proof of income (e.g., Federal Tax Return, W-2, or pay stubs)

Prescription from a licensed practitioner

If You Don't Qualify for the Assistance Program

Manufacturer Savings Card (for insured patients)

Bristol Myers Squibb offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.

Common Questions

How long does it take to find out if I am approved for free Reblozyl through BMSPAF?

BMSPAF typically completes its review within two business days after receiving your complete application. Make sure all required documents are included — missing paperwork is the most common reason for delays.

I have Medicare Part D. Can I still apply for the BMSPAF program?

Yes, you may still qualify. Unlike many patient assistance programs that exclude Medicare patients entirely, BMSPAF allows Medicare Part D beneficiaries to apply if they meet the income requirements and can demonstrate financial hardship. Call (800) 736-0003 to discuss your specific situation.

Do I need to reapply every year?

Yes. BMSPAF requires annual reauthorization to confirm that you still meet the eligibility criteria. Your prescriber's office may assist with the renewal process, but you should track your approval date to avoid any gap in your Reblozyl supply.

Where will my Reblozyl be delivered if I am approved?

If approved, Reblozyl is shipped directly to your prescriber's office — not to your home. Your doctor's office will notify you when the medication arrives and coordinate your treatment schedule.

What if my income is slightly over the limit listed in the guide?

You may still want to contact BMSPAF directly at (800) 736-0003. Income limits can vary based on household size beyond four people, and individual circumstances may be reviewed on a case-by-case basis. If you do not qualify, the Reblozyl savings card at https://www.reblozyl.com/patient/support-and-resources may be an option if you have private insurance.

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RX Advantages handles the entire Bristol Myers Squibb Patient Assistance Foundation (BMSPAF) application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.

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