Rydapt (midostaurin)
Patient Assistance Program Guide — Novartis Patient Assistance Foundation (NPAF)
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured, underinsured, or Medicare Part D patients who meet specific financial and clinical criteria.
Residency
U.S. resident, permanent resident, or legal alien with a valid U.S. address.
Income Limits (500% FPL)
Threshold is generally 500% of FPL for oncology products like Rydapt; based on 2025 HHS guidelines.
Based on 2025 HHS Federal Poverty Level guidelines.
# Rydapt (Midostaurin) Patient Assistance Guide: How to Apply for the Novartis Patient Assistance Foundation (NPAF)
---
Who Qualifies for the Novartis Patient Assistance Foundation (NPAF)?
If you need Rydapt (midostaurin) and cannot afford it, you may be able to get it at no cost through the Novartis Patient Assistance Foundation (NPAF). This program is designed to help patients who meet specific income and insurance requirements. For a single-person household, your annual income must generally be at or below $75,300 to qualify. In terms of insurance, the program is primarily open to patients who are uninsured, underinsured, or enrolled in Medicare Part D and who do not have adequate prescription coverage. If you meet these criteria, the NPAF may provide Rydapt to you free of charge.
---
About Rydapt (Midostaurin)
Rydapt (midostaurin) is an FDA-approved prescription medication used to treat adults with certain serious blood-related conditions. These include Acute Myeloid Leukemia (AML) in patients who have a specific FLT3 gene mutation, as well as Aggressive Systemic Mastocytosis (ASM), Systemic Mastocytosis with Associated Hematological Neoplasm (SM-AHN), and Mast Cell Leukemia (MCL). Rydapt belongs to a class of drugs called kinase inhibitors, specifically a FLT3 inhibitor. Because it is a specialty oncology medication with no FDA-approved biosimilar alternatives currently available, the out-of-pocket cost without insurance or assistance can be extremely high — making programs like NPAF critically important for eligible patients.
---
Income Eligibility: Full Breakdown
The NPAF uses income thresholds set at approximately 500% of the Federal Poverty Level (FPL), based on 2025 HHS guidelines. Your household size determines the maximum income allowed. The table below shows the current limits:
| Household Size | Max Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Income is typically verified using your most recent federal tax return (Form 1040), a W-2, or three months of recent pay stubs. If your income is slightly above these limits, it is still worth contacting the NPAF directly — some programs allow case-by-case review or consider extenuating financial circumstances. If you have a larger household not shown above, the income threshold generally increases with each additional person. Do not assume you are ineligible without speaking with a program representative, as household composition and income calculations may allow for more flexibility than the standard table suggests.
---
Insurance Requirements Explained
Your insurance status plays a major role in whether you qualify for the NPAF. Here is how the program typically handles different situations:
---
Step-by-Step: How to Apply
Follow these steps to apply for free Rydapt through the NPAF:
1. Gather your documents. You will need: a completed and signed application form (both the patient section and the prescriber section), proof of income (your most recent federal tax return, W-2, or Form 1040), and a valid prescription for Rydapt from your doctor.
2. Get the application form. Visit the official NPAF page at https://www.novartis.com/us-en/patients-and-caregivers/patient-assistance/novartis-patient-assistance-foundation-inc to download or access the application. You can also call (800) 277-2254 to request a paper form.
3. Complete both sections. Fill out the patient portion yourself, and make sure your prescribing doctor completes and signs the prescriber section. Both signatures are required.
4. Submit your application. You may apply online through the Novartis website, fax your completed application and documents to (888) 891-4924, or submit by phone by calling (800) 277-2254 to ask about your options.
5. Wait for a decision. Processing typically takes 2 to 5 business days after all required documents are received.
6. Receive your medication. If approved, Rydapt will be shipped directly to your home address.
---
What to Expect: Timeline and Delivery
Once your completed application and all supporting documents are submitted, the NPAF typically processes your request within 2 to 5 business days. You or your doctor's office will be notified of the approval decision. If approved, Rydapt is shipped directly to your home — you do not need to pick it up at a pharmacy or your doctor's office. Make sure your shipping address is clearly noted on the application. Your enrollment in the NPAF is not permanent — reauthorization is required annually. Before your approval period ends, you will need to reapply and resubmit updated income documentation to continue receiving the medication at no cost.
---
Alternatives If You Don't Qualify
If you do not meet the NPAF income or insurance requirements, here are other options to explore:
1. Biosimilars: There are currently no FDA-approved biosimilar alternatives to Rydapt (midostaurin), so this option is not available at this time.
2. Manufacturer savings card: If you have commercial (private) insurance, Novartis offers a savings card program for Rydapt that may reduce your out-of-pocket costs significantly. You can find more information at https://www.hcp.novartis.com/products/rydapt/aml/patient-financial-support/.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states run their own drug assistance programs, particularly for seniors or low-income residents. Contact your state health department or ask your doctor's office to help identify programs in your state.
4. NeedyMeds.org: This free online database at www.needymeds.org lists hundreds of assistance programs, including disease-specific funds and local resources that may help cover your Rydapt costs.
---
*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Novartis. Program terms may change — verify current requirements at [https://www.novartis.com/us-en/patients-caregivers/patient-assistance](https://www.novartis.com/us-en/patients-caregivers/patient-assistance) before applying.*
---
Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Novartis offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Yes. Unlike some patient assistance programs, the Novartis Patient Assistance Foundation does include Medicare Part D patients. You will need to meet income and clinical eligibility requirements and disclose your Medicare coverage on the application.
The NPAF typically processes completed applications within 2 to 5 business days. Once approved, your medication is shipped directly to your home. Delays can occur if your application is missing documents, so make sure all sections are signed and income proof is included.
Your NPAF enrollment must be renewed every year. Before your current approval period expires, you will need to submit a new application along with updated proof of income. Your doctor will also need to complete the prescriber section again. Plan ahead to avoid a gap in your medication supply.
It is still worth applying or calling the NPAF at (800) 277-2254. In some cases, the program may consider special financial circumstances. Do not assume you are ineligible without speaking to a representative first.
If you are approved for the Novartis Patient Assistance Foundation program, Rydapt is provided to you at no charge. There is no application fee. The medication is shipped directly to your home at no cost to you.
Ready to Apply for Rydapt Assistance?
RX Advantages handles the entire Novartis Patient Assistance Foundation (NPAF) application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month