Soliris (eculizumab)
Patient Assistance Program Guide — Alexion OneSource / AstraZeneca Patient Assistance Program
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured or underinsured; commercially insured patients may utilize the co-pay program; Medicare/government-insured patients may be eligible for the free drug program if they meet specific hardship criteria.
Residency
U.S. resident or legal resident with a valid address
Income Limits (500% FPL)
Alexion/AstraZeneca rare disease programs typically utilize a 500% FPL threshold, though case-by-case reviews occur for higher incomes.
Based on 2025 HHS Federal Poverty Level guidelines.
# Soliris (Eculizumab) Patient Assistance Guide
Alexion OneSource / AstraZeneca Patient Assistance Program
---
Who Qualifies for the Alexion OneSource / AstraZeneca Patient Assistance Program?
If you take Soliris (eculizumab) and are struggling to afford it, the Alexion OneSource / AstraZeneca Patient Assistance Program may be able to help you get your medication free or at a significantly reduced cost. Single-person households with an annual income at or below $75,300 are typically eligible. Your insurance situation also plays a role: patients who are uninsured or underinsured may qualify for free drug, commercially insured patients may access co-pay assistance, and Medicare patients may be eligible if they meet specific financial hardship criteria. Income and insurance requirements are reviewed together, so even if you are unsure whether you qualify, it is worth applying. RX Advantages can help you navigate the process.
---
About Soliris (Eculizumab)
Soliris (eculizumab) is a prescription biologic medication manufactured by Alexion, an AstraZeneca rare disease company. It belongs to a drug class called complement inhibitors and works by targeting a specific protein in the immune system. Soliris is FDA-approved to treat four serious rare conditions: paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and neuromyelitis optica spectrum disorder (NMOSD). Because it is a biologic drug requiring complex manufacturing and ongoing infusion administration, Soliris carries one of the highest list prices of any medication available. Without insurance or assistance, the annual cost can be financially devastating for most patients and families.
---
Income Eligibility: Full Breakdown
The Alexion OneSource program uses income thresholds based on approximately 500% of the Federal Poverty Level (FPL). The table below shows the maximum annual income allowed based on your household size:
| Household Size | Max Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
For households larger than four people, income limits increase with each additional member. Income is typically verified using your most recent federal tax return, a W-2, or a 1099 form. If your income has recently changed, some programs will accept three months of recent pay stubs instead.
If your income is above these limits, do not assume you are automatically disqualified. Alexion conducts case-by-case reviews for patients with extraordinary medical expenses or financial hardship. It is still worth submitting an application or calling the program directly at (888) 765-4747 to ask about exceptions. Program staff can often advise you on whether a review is appropriate for your situation.
---
Insurance Requirements Explained
Your insurance status determines which part of the Alexion OneSource program applies to you:
---
Step-by-Step: How to Apply
Follow these steps to apply for the Alexion OneSource / AstraZeneca Patient Assistance Program:
1. Gather your documents before you start. You will need: proof of income (most recent tax return, W-2, or 1099), your insurance card or a denial letter from your insurer, your prescriber's contact information and a current prescription for Soliris, and a signed patient consent form.
2. Choose your application method. You can apply online at https://alexiononesource.com/, call the program at (888) 765-4747 to apply by phone or request paper forms, or fax a completed application to (800) 420-7557.
3. Complete the application fully. Incomplete applications are a common reason for delays. Double-check that all fields are filled in and that your prescriber has signed where required.
4. Submit your supporting documents along with your application. If applying online, upload scanned or photographed copies. If faxing, send all documents together in one transmission.
5. Confirm receipt. After submitting, call (888) 765-4747 to confirm your application was received and to ask about your case status.
6. Your prescriber will be notified of the approval decision. If approved, medication will be arranged for shipment directly to your prescriber's office.
---
What to Expect: Timeline and Delivery
After submitting a complete application, processing typically takes 7 to 10 business days. Alexion OneSource will notify your prescriber of the approval decision. Soliris is shipped directly to your prescriber's office or infusion center, not to your home, since it is administered by a healthcare provider. You do not need to pick up or transport the medication yourself. Once approved, your enrollment is valid for one year, after which you must reauthorize. Alexion will typically send a reauthorization reminder before your approval expires, but it is a good idea to track your renewal date so there is no interruption in your treatment.
---
Alternatives If You Don't Qualify
If you do not meet the income or insurance requirements for the free drug program, you still have options:
1. Biosimilar alternatives: Two FDA-approved biosimilars to Soliris are available and may be covered at a lower cost — Beksomy (eculizumab-aeeb) and Epysqli (eculizumab-aagh). Ask your prescriber if either may be appropriate for you.
2. Co-pay savings card: If you have commercial insurance, Alexion offers a savings card program that can reduce your out-of-pocket costs. Apply at https://alexiononesource.com/copay-assistance.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer additional drug assistance for residents who do not qualify for federal programs. Contact your state health department to ask what is available in your state.
4. NeedyMeds.org: This free, independent database lists hundreds of patient assistance programs, disease-specific funds, and drug discount options. It is a helpful starting point if you are exploring multiple avenues.
---
*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Alexion / AstraZeneca. Program terms may change — verify current requirements at [https://www.alexion.com/patients/patient-assistance-programs](https://www.alexion.com/patients/patient-assistance-programs) before applying.*
---
Documents You'll Need
If You Don't Qualify for the Assistance Program
Biosimilar / Generic Alternatives
FDA-approved alternatives to Soliris: Beksomy (eculizumab-aeeb), Epysqli (eculizumab-aagh). Ask your prescriber if one of these is clinically appropriate for your condition.
Manufacturer Savings Card (for insured patients)
Alexion / AstraZeneca offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Processing typically takes 7 to 10 business days after Alexion receives your complete application and all required documents. Missing paperwork is the most common cause of delays, so make sure your income proof, insurance information, prescriber signature, and patient consent form are all included before submitting.
Medicare patients are not automatically excluded. While federal rules prevent many standard assistance programs from serving Medicare Part D beneficiaries, Alexion's rare disease program may make exceptions for patients who can show specific financial hardship. Call (888) 765-4747 to discuss your situation directly with a program representative.
You will need to reauthorize your enrollment each year. Alexion OneSource typically sends a reminder before your approval expires. To avoid any gap in your medication, start gathering updated income documents and contact your prescriber for a renewed prescription before your current approval period ends.
Yes. Alexion conducts case-by-case reviews for patients whose income exceeds the standard thresholds, especially when significant medical expenses are involved. Applying or calling (888) 765-4747 to explain your circumstances costs nothing, and a program representative can tell you whether a hardship review is an option for you.
No. Because Soliris is administered by a healthcare provider through an infusion, approved medication is shipped directly to your prescriber's office or infusion center. You do not need to arrange pickup or transportation for the drug itself.
Ready to Apply for Soliris Assistance?
RX Advantages handles the entire Alexion OneSource / AstraZeneca Patient Assistance Program application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month