Tagrisso (osimertinib)
Patient Assistance Program Guide — AZ&Me Prescription Savings Program
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured, underinsured, or Medicare Part D patients who meet specific financial and clinical criteria.
Residency
U.S. resident or legal resident with a valid U.S. address
Income Limits (500% FPL)
Income threshold calculated at 500% of 2025 FPL for oncology/specialty products.
Based on 2025 HHS Federal Poverty Level guidelines.
# AZ&Me Prescription Savings Program: A Patient Guide to Getting Tagrisso at Low or No Cost
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Who Qualifies for the AZ&Me Prescription Savings Program?
If you take Tagrisso (osimertinib) for non-small cell lung cancer and are struggling with the cost, the AZ&Me Prescription Savings Program from AstraZeneca may be able to help you get your medication for free or at a significantly reduced cost. To qualify, you generally need to meet income and insurance requirements set by AstraZeneca. For a single-person household, the maximum annual income limit is $75,300. In terms of insurance, the program is designed for patients who are uninsured, underinsured, or enrolled in Medicare Part D and who meet specific financial and clinical criteria. If that sounds like your situation, this guide will walk you through everything you need to know.
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About Tagrisso (osimertinib)
Tagrisso is a prescription medication made by AstraZeneca. It belongs to a class of drugs called EGFR tyrosine kinase inhibitors, sometimes referred to as kinase inhibitors. It is FDA-approved to treat adults with non-small cell lung cancer (NSCLC) whose tumors have certain EGFR mutations. Your doctor will confirm whether your cancer has the specific mutation that Tagrisso targets. Without insurance or financial assistance, Tagrisso can cost tens of thousands of dollars per month, making it out of reach for many patients. Programs like AZ&Me exist specifically to bridge that gap so that cost does not become a barrier to staying on your prescribed treatment plan.
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Income Eligibility: Full Breakdown
The AZ&Me Prescription Savings Program uses income thresholds set at 500% of the 2025 Federal Poverty Level (FPL) for specialty oncology products like Tagrisso. Your eligibility is based on your total household income, not just your personal income. Here is how the limits break down by household size:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
When you apply, your income is typically verified using your most recent federal tax return (Form 1040 or W-2) or three months of recent pay stubs if your tax return is not available or does not reflect your current income situation.
If your income is above these limits, you may not qualify for the free medication program. However, that does not necessarily mean you are out of options. See the section below on alternatives, including savings cards for insured patients and other assistance programs that may still be able to help reduce your costs.
Larger households generally have higher income limits, so if you support a family, make sure to report your full household size accurately on your application. This can make a meaningful difference in whether you qualify.
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Insurance Requirements Explained
Your insurance status plays a major role in determining how the AZ&Me program can help you. Here is a simple breakdown based on your current coverage:
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Step-by-Step: How to Apply
Follow these steps to apply for the AZ&Me Prescription Savings Program:
1. Gather your documents before you start. You will need a completed application form with your physician's signature, proof of income (such as a Form 1040, W-2, or three months of recent pay stubs), and a valid prescription for Tagrisso.
2. Choose your application method. You can apply in one of three ways:
- Online: Visit https://www.azandmeapp.com/ to complete and submit your application digitally.
- By phone: Call (800) 292-6363 to speak with a program representative who can guide you through the process.
- By fax: Fax your completed application and supporting documents to (800) 961-8323.
3. Have your doctor complete their portion. The application requires a physician signature confirming your diagnosis and prescription. Coordinate with your oncologist's office early, as this step can sometimes take a few days.
4. Submit your income documentation. Attach whichever income proof applies to your situation — your most recent tax return or recent pay stubs.
5. Submit your complete application. Incomplete applications may cause delays, so double-check that all sections are filled out and all documents are included before sending.
6. Wait for a decision. Processing typically takes 7 to 10 business days from the time your complete application is received.
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What to Expect: Timeline and Delivery
Once your application is submitted with all required documents, processing typically takes 7 to 10 business days. AstraZeneca or the program administrator will notify you — and often your prescriber's office — of the approval decision. If approved, your Tagrisso will be shipped directly to your home address, so you do not need to pick it up at a pharmacy or your doctor's office. Make sure someone is available to receive the shipment, as it may require a signature. Enrollment in the program is not permanent — you will need to reapply once a year to maintain your benefits. Watch for renewal reminders from the program so your medication does not lapse.
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Alternatives If You Don't Qualify
If you do not qualify for AZ&Me, here are other options worth exploring:
1. Biosimilars: There are currently no FDA-approved biosimilar alternatives to Tagrisso (osimertinib). Tagrisso is a small-molecule drug, not a biologic, so this option is not available at this time.
2. Manufacturer savings card (for insured patients): If you have private insurance, AstraZeneca offers a separate cost-support program that may reduce your out-of-pocket costs significantly. Visit https://www.tagrisso.com/cost-support.html for details.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states run their own prescription assistance programs, especially for Medicare beneficiaries. Eligibility and benefits vary by state. Contact your state's department of health or aging to ask about available programs.
4. NeedyMeds.org: This free, nonprofit database at www.needymeds.org lists hundreds of patient assistance programs, disease-specific funds, and other resources. It is a useful tool if you need to explore multiple options at once.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by AstraZeneca. Program terms may change — verify current requirements at [https://www.tagrisso.com/patient-support/financial-support.html](https://www.tagrisso.com/patient-support/financial-support.html) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
AstraZeneca offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Yes. Unlike many patient assistance programs that exclude Medicare Part D patients, the AZ&Me Prescription Savings Program may still be an option for you if you meet the income and clinical eligibility requirements. Call (800) 292-6363 to confirm your specific situation before applying.
Processing typically takes 7 to 10 business days after AstraZeneca receives your complete application. Once approved, your medication is shipped directly to your home. Make sure your application is fully completed — missing documents are one of the most common reasons for delays.
You can use your most recent federal tax return (Form 1040 or W-2) to verify your income. If your tax return does not reflect your current income, three months of recent pay stubs are also accepted. Gather these before you start your application to avoid delays.
Yes. The AZ&Me program requires annual reauthorization. You will need to submit a new application each year to continue receiving benefits. Watch for renewal notices from the program to make sure your medication does not lapse between enrollment periods.
It is generally worth speaking with a program representative before assuming you do not qualify. Call (800) 292-6363 to discuss your situation. If you do not qualify for AZ&Me, a representative may be able to point you toward other options, such as the savings card program for insured patients or state pharmaceutical assistance programs.
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