Tezspire (tezepelumab)
Patient Assistance Program Guide — AZ&Me Prescription Savings Program
Do You Qualify?
Income
Up to $90,360 for a single person
Insurance
Must be uninsured, underinsured, or have Medicare Part D. Commercial insurance is eligible if the drug is not covered.
Residency
U.S. resident with a valid address or U.S. territory resident.
Income Limits (600% FPL)
Income limits calculated based on 600% of the 2025 FPL. This is the standard threshold for AstraZeneca specialty biologics.
Based on 2025 HHS Federal Poverty Level guidelines.
# A Patient Guide to the AZ&Me Prescription Savings Program for Tezspire (tezepelumab)
Prepared by RX Advantages
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Who Qualifies for the AZ&Me Prescription Savings Program?
If you have been prescribed Tezspire (tezepelumab) for severe asthma, you may be able to get it at little or no cost through the AZ&Me Prescription Savings Program, offered by AstraZeneca. For a single-person household, the maximum annual income allowed is $90,360. Income limits are higher if your household includes more people, so do not assume you are ineligible before checking the full table below. In terms of insurance, the program is open to patients who are uninsured, underinsured, enrolled in Medicare Part D, or have private insurance that does not cover Tezspire. If you think you might qualify, the program is worth applying for — Tezspire is a high-cost biologic that can be difficult to afford without help.
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About Tezspire (tezepelumab)
Tezspire (tezepelumab) is a biologic medication approved by the FDA as an add-on maintenance treatment for adults and adolescents aged 12 and older with severe asthma. It belongs to a drug class called thymic stromal lymphopoietin (TSLP) blockers and is administered by injection. Tezspire is manufactured by AstraZeneca and Amgen. Because it is a specialty biologic, the list price is very high — often tens of thousands of dollars per year — putting it out of reach for many patients without insurance coverage or financial assistance. There are currently no FDA-approved biosimilar versions of tezepelumab available, which means lower-cost alternatives in the same drug class do not yet exist.
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Income Eligibility: Full Breakdown
The AZ&Me Prescription Savings Program uses income thresholds set at 600% of the 2025 Federal Poverty Level. The table below shows the maximum annual household income allowed for each household size:
| Household Size | Maximum Annual Income |
|---|---|
| 1 person | $90,360 |
| 2 persons | $122,640 |
| 3 persons | $154,920 |
| 4 persons | $187,200 |
When you apply, AstraZeneca will typically verify your income using your most recent federal tax return, your most recent W-2, or three months of recent pay stubs. If your income is close to the limit, it is still worth applying — household size is factored in, so a family of three or four may qualify even with a higher combined income.
If your income is above the limit for your household size, you will likely not qualify for free medication through this program. In that case, see the "Alternatives If You Don't Qualify" section below for other options that may help reduce your out-of-pocket costs.
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Insurance Requirements Explained
Your insurance status plays an important role in whether you qualify. Here is how the program handles different situations:
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Step-by-Step: How to Apply
Follow these steps to apply for the AZ&Me Prescription Savings Program for Tezspire:
1. Gather your documents before you start. You will need: proof of income (most recent tax return, W-2, or three months of pay stubs), a valid prescription for Tezspire, a copy of your insurance card if you have insurance, and the completed physician section of the application form.
2. Ask your doctor's office to help. The application requires a section completed by your prescriber. Many offices are familiar with this process — let them know you are applying for the AZ&Me program.
3. Choose your application method:
- Online (fastest): Visit https://www.azandmeapp.com/ to complete and submit the application digitally.
- By phone: Call (800) 292-6363 to apply with a program representative or ask questions.
- By fax: Submit your completed paper application by fax to (800) 961-8323.
4. Submit all required documents along with your application. Incomplete applications may delay processing.
5. Wait for a determination. Processing typically takes 7 to 10 business days after your complete application is received.
6. Confirm your approval with your doctor's office and make sure they know medication will be shipped to their location.
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What to Expect: Timeline and Delivery
After you submit a complete application, expect a decision within 7 to 10 business days. Once approved, your Tezspire will be shipped directly to your prescriber's office — not to your home. Your doctor's staff will contact you to schedule your injection appointment. You do not need to pick up or handle the shipment yourself. The program requires annual reauthorization, meaning you will need to renew your enrollment once a year to continue receiving the medication. Your prescriber or the program may send a reminder when renewal is approaching, but it is a good idea to track your approval date and plan ahead.
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Alternatives If You Don't Qualify
If you do not meet the income or insurance requirements for the AZ&Me program, you still have options:
1. Biosimilars: There are currently no FDA-approved biosimilars for tezepelumab. This option is not yet available, but may become one in the future.
2. Manufacturer savings card: If you have commercial insurance that covers Tezspire but still face high out-of-pocket costs, AstraZeneca offers a separate savings card program for insured patients. Visit https://www.tezspire.com/savings-and-support.html to learn more and see if you are eligible.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states run their own drug assistance programs, particularly for older adults and people with disabilities. Search for your state's SPAP through your state health department website.
4. NeedyMeds.org: This free, independent database at https://www.needymeds.org lists hundreds of assistance programs by drug name, diagnosis, and state. It is a helpful starting point if you need to explore additional options.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by AstraZeneca / Amgen. Program terms may change — verify current requirements at [https://www.tezspire.com/support](https://www.tezspire.com/support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
AstraZeneca / Amgen offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Yes. The AZ&Me Prescription Savings Program accepts patients with Medicare Part D, which is not the case with many other manufacturer assistance programs. You will still need to meet the income requirements for your household size.
After AstraZeneca receives your complete application — including the physician section and all required documents — processing typically takes 7 to 10 business days. Once approved, the medication is shipped to your prescriber's office, so allow additional time for shipping and scheduling your injection appointment.
You will need to provide proof of your household income. Accepted documents typically include your most recent federal tax return, a W-2, or three months of recent pay stubs. If your income situation is unusual, contact the program at (800) 292-6363 to ask what documentation may be accepted.
Yes. The AZ&Me program requires annual reauthorization. You will need to resubmit your application and updated income documentation once a year to continue receiving Tezspire through the program. It is a good idea to track your approval date so you are not caught off guard when renewal is due.
Yes. Patients with commercial insurance may qualify if their plan does not cover Tezspire. You will need to provide a copy of your insurance card and documentation showing that the drug is not covered under your plan. Contact the program at (800) 292-6363 if you need guidance on what documentation to submit.
Ready to Apply for Tezspire Assistance?
RX Advantages handles the entire AZ&Me Prescription Savings Program application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month