Vyndaqel (tafamidis)
Patient Assistance Program Guide — Pfizer RxPathways / Vyndalink Support Program
Do You Qualify?
Income
Up to $75,300 for a single person
Insurance
Uninsured or underinsured; patients with commercial insurance or Medicare Part D may qualify for specific program components if they meet financial criteria and insurance coverage requirements.
Residency
U.S. resident with valid address
Income Limits (500% FPL)
Calculated at 500% FPL for Pfizer specialty cardiology medicines; income limits may vary based on cost of living or specific hardship.
Based on 2025 HHS Federal Poverty Level guidelines.
# Getting Vyndaqel (Tafamidis) at Low or No Cost Through the Pfizer RxPathways / Vyndalink Support Program
Who Qualifies for the Pfizer RxPathways / Vyndalink Support Program?
If you have been prescribed Vyndaqel (tafamidis) for transthyretin-mediated amyloid cardiomyopathy (ATTR-CM), you may be able to get it free or at a significantly reduced cost through the Pfizer RxPathways / Vyndalink Support Program. This program is designed to help patients who cannot afford the high out-of-pocket cost of this medication. If you are a single-person household, your annual income must be at or below $75,300 to qualify for free medication. Patients who are uninsured or underinsured are the primary focus of this program, but those with commercial insurance or Medicare Part D may also qualify for certain program components if they meet specific financial and coverage requirements.
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About Vyndaqel (Tafamidis)
Vyndaqel (tafamidis) is a prescription medication made by Pfizer. It is approved by the U.S. Food and Drug Administration (FDA) to treat transthyretin-mediated amyloid cardiomyopathy (ATTR-CM), a serious heart condition caused by a buildup of misfolded transthyretin protein in the heart. Vyndaqel belongs to a drug class called transthyretin stabilizers. Without insurance or financial assistance, Vyndaqel carries a very high list price — often exceeding $200,000 per year — making it one of the more expensive specialty medications on the market. For many patients, the Pfizer RxPathways / Vyndalink Support Program is a critical resource that makes ongoing access to this treatment possible.
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Income Eligibility: Full Breakdown
The Pfizer RxPathways / Vyndalink Support Program uses income thresholds set at approximately 500% of the Federal Poverty Level (FPL) for specialty cardiology medicines like Vyndaqel. The table below shows the maximum annual household income allowed by household size:
| Household Size | Max Annual Income |
|---|---|
| 1 person | $75,300 |
| 2 persons | $102,200 |
| 3 persons | $129,100 |
| 4 persons | $156,000 |
Your income is typically verified using your most recent federal tax return or three months of recent pay stubs. If you are self-employed or your income has changed significantly since last year, other documentation may be accepted.
If your income is above these limits, you may not qualify for the free medication program. However, you should still call (888) 222-8475 to speak with a program specialist — in some cases, Pfizer considers cost-of-living adjustments or documented financial hardship. Income limits may also vary in certain circumstances, so it is worth asking directly rather than assuming you do not qualify.
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Insurance Requirements Explained
Your insurance status plays an important role in determining which part of the program you can access:
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Step-by-Step: How to Apply
Follow these steps to apply for the Pfizer RxPathways / Vyndalink Support Program:
1. Visit the program website at https://www.vyndaqel.com/financial-support to begin your application online, or call (888) 222-8475 to request a paper application by mail or to apply over the phone with a program specialist.
2. Gather your required documents before you start. You will need:
- A signed application form (available online or by phone)
- Proof of household income (most recent federal tax return, W-2, or three months of pay stubs)
- Your current prescription information for Vyndaqel
- Insurance cards for any active coverage you have, if applicable
3. Have your prescriber complete their portion of the application. Most forms require a healthcare provider signature and information about your diagnosis and prescription.
4. Submit your application online at the link above, by fax to (844) 639-5100, or by following the mailing instructions on the form.
5. Wait for a decision. Processing typically takes 7 to 10 business days after all required documents are received. A program representative will contact you or your prescriber with the outcome.
6. Contact RX Advantages at any point during this process if you need help gathering documents, completing forms, or following up on a pending application.
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What to Expect: Timeline and Delivery
Once your application is approved, you can expect to receive confirmation within 7 to 10 business days from the time Pfizer receives your complete application. Approval notices are typically sent to both you and your prescriber. Vyndaqel is shipped directly to your home, so you do not need to pick it up at a pharmacy or your doctor's office. Make sure your shipping address is accurate on your application. Your enrollment in the program is not permanent — you will need to reauthorize your eligibility once per year. Pfizer will typically notify you and your prescriber before your enrollment period ends so you can submit updated income documentation and a renewal form in time to avoid a gap in your medication supply.
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Alternatives If You Don't Qualify
If you do not qualify for the free medication program, there are still options to explore:
1. Biosimilars: There are currently no FDA-approved biosimilar alternatives to Vyndaqel. This means there is no lower-cost generic or biosimilar version available at this time.
2. Manufacturer co-pay savings card: If you have commercial (private) insurance, you may qualify for Pfizer's co-pay assistance card for Vyndaqel, which can reduce your out-of-pocket costs at the pharmacy. Apply at https://www.vyndaqel.com/co-pay-card.
3. State Pharmaceutical Assistance Programs (SPAPs): Many states offer programs that help residents pay for high-cost prescription drugs. Eligibility varies by state. Contact your state health department or ask a patient advocate for details.
4. NeedyMeds.org: This free online database at www.needymeds.org lists patient assistance programs, SPAPs, disease-based assistance funds, and other resources organized by drug name and condition.
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*This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by Pfizer. Program terms may change — verify current requirements at [https://www.vyndaqel.com/patient-support](https://www.vyndaqel.com/patient-support) before applying.*
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Documents You'll Need
If You Don't Qualify for the Assistance Program
Manufacturer Savings Card (for insured patients)
Pfizer offers a savings card that may reduce your out-of-pocket cost if you have commercial insurance. Ask your prescriber or pharmacist for current savings card details.
Common Questions
Processing typically takes 7 to 10 business days after Pfizer receives your complete application, including all required documents and your prescriber's signature. Incomplete applications may take longer, so make sure everything is submitted together.
If you are approved, Vyndaqel is shipped directly to your home address. You do not need to pick it up at a pharmacy or visit your prescriber's office to receive it. Make sure the address on your application is current and accurate.
Yes. The program requires annual reauthorization. You will need to submit updated income documentation and a renewal form each year to continue receiving assistance. Pfizer typically notifies you and your prescriber before your enrollment period expires.
Possibly. While many assistance programs exclude Medicare beneficiaries, the Pfizer RxPathways / Vyndalink Support Program has provisions for some Medicare Part D patients who face significant out-of-pocket costs and meet income requirements. Call (888) 222-8475 to find out what options may be available to you.
Yes, it is still worth contacting the program. In some cases, Pfizer may consider cost-of-living factors or documented financial hardship when reviewing applications. Call (888) 222-8475 or visit https://www.vyndaqel.com/financial-support to discuss your situation with a program specialist.
Ready to Apply for Vyndaqel Assistance?
RX Advantages handles the entire Pfizer RxPathways / Vyndalink Support Program application on your behalf — paperwork, physician coordination, and refill tracking. It takes about 15 minutes to get started.
No SSN required on the web form · From $49.95/month